engleski

The effect of 3-weeks stationary cardiac rehabilitation on plasma lipids level in 444 patients with coronary heart disease

The normalization of plasma lipids level have an important role in the prevention of coronary heart disease (CHD). The aim of this study was to investigate the effect of 3- weeks stationary cardiac rehabilitation on plasma lipids level in patients with CHD. The study included 444 consecutive patients (364 male and 80 female, mean age 58 &plusmn ; ; 9 year) with CHD who underwent 3-weeks stationary cardiac rehabilitation. Patients were divided into groups depending on their baseline levels of cholesterol and medication therapy: patients with normal (< 5 mmol/L , group I, 129 patients) and elevate plasma level of Total cholesterol (> 5 mmol/L, group II , 315 patients) and subgroups Ia and IIa (with statin in therapy), Ib and IIb (without statin in therapy). The full lipid profile was done before the start and at the last day of rehabilitation. The results are expressed by mean values &plusmn ; ; standard deviation and percentage of change of each plasma lipids level at the end of rehabilitation in comparison with baseline values. The differences between the groups were tested by analysis of variance with repeated measures. After 3-weeks cardiac rehabilitation, the levels of Total cholesterol 5.75 &plusmn ; ; 1.34 vs. 5.17 &plusmn ; ; 1.08 mmol/l ; p<0.001, triglycerides 2.04 &plusmn ; ; 1.33 vs. 1.81 &plusmn ; ; 1.06 mmol/L ; p=0.004, LDL- cholesterol 3.77 &plusmn ; ; 1.14 vs. 3.21 &plusmn ; ; 0.96 mmol/L ; p<0.001 were significantly lower while the level of HDL-cholesterol 0.94 &plusmn ; ; 0.28 vs. 0.99 &plusmn ; ; 0.27 mmol/L ; p=0.008 were significantly higher in comparison with the baseline values. Furthermore, we found significant changes in lipid profile at the end of rehabilitation in each group of patients compared with the baseline values. There were no significant differences in plasma lipids level between group of patients with or without statin in therapy at the end of rehabilitation. The results of this study suggest that moderate regular physical activity and diet alone or in combination with hypolipidemic drugs already after 3 weeks have a favourable effect on plasma lipids level and should be propagate in the prevention of CHD.

lipids; cholesterol; triglycerides; rehabilitation; coronary heart disease

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