engleski

Change in Bone Mineral Density in Patients with Urolithiasis: a Follow-Up Study

The purpose of this investigation was to assess the bone mineral content (BMC) and bone mineral density (BMD) over a period of one year in patients with urolithiasis and to determine the factors that could have influenced the changes in bone density during that period. The patient group comprised 34 men, aged 41.2&plusmn ; ; 7.9 years with recurrent urolithiasis. A wide spectrum of biochemical measurements was performed. Bone mineral density (g/cm^2), bone mineral content (BMC) and bone area (BA) were measured twice over a period of one year, at the lumbar spine (L2-L4), femoral neck, Ward's triangle and trochanter, using dual energy absorptiometry. Patients' results were compared to those obtained from 30 healthy male controls of a comparable age group. Nine patients were hypercalciuric, while most of other metabolic parameters were within the reference values. Bone mineral content and bone areas at all regions were lower in patients comparing to controls, but not significantly. The biggest annual reduction of BMD was noticed at the Ward's triangle (-5.70% in patients and -2.36% in controls), following with femoral neck (-4.06% patients, -2.03% controls) and trochanter (-3.06% patients, -1.39% controls). There was no significant decrease of the BMD of the spine. Analysing the influence of age, body mass index, metabolic parameters and dietary calcium intake on the annual reduction of bone density, we found that age, hyperuricosuria and calcium intake were significantly associated with the bone loss in that time period. Bone mass reduction in patients with urolithiasis over a one year period did not differ significantly from that in controls and was mostly related to age, hyperuricosuria and calcium dietary restriction, but not to increased calcium excretion.

bone mineral density; patients with urolithiasis; metabolic parameters

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