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Pregled bibliografske jedinice broj: 250405

The Effect of Chemical Structure and Stereochemistry on Interactions of Immunomodulatory Peptides with Lipid Bilayers in Liposomes


Frkanec, Ruža; Travaš, Dijana; Nöthig Laslo, Vesna; Mirosavljević Krunoslav; Krstanović, Marina; Vranešić, Branka; Tomašić, Jelka
The Effect of Chemical Structure and Stereochemistry on Interactions of Immunomodulatory Peptides with Lipid Bilayers in Liposomes // Peptides 2004. Proceedings of the 3^rd International and 28^th European Peptide Symposium / Flegel, Martin ; Fridkin, Mati ; Gilon, Chaim ; Slaninova, Jirina (ur.).
Geneva: Kenes International, 2005. str. 1115-1116 (poster, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)


CROSBI ID: 250405 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The Effect of Chemical Structure and Stereochemistry on Interactions of Immunomodulatory Peptides with Lipid Bilayers in Liposomes

Autori
Frkanec, Ruža ; Travaš, Dijana ; Nöthig Laslo, Vesna ; Mirosavljević Krunoslav ; Krstanović, Marina ; Vranešić, Branka ; Tomašić, Jelka

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Peptides 2004. Proceedings of the 3^rd International and 28^th European Peptide Symposium / Flegel, Martin ; Fridkin, Mati ; Gilon, Chaim ; Slaninova, Jirina - Geneva : Kenes International, 2005, 1115-1116

Skup
3^rd International and 28^th European Peptide Symposium

Mjesto i datum
Prag, Češka Republika, 5.9.-10.9.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
peptidoglycan monomer; adamantyltripeptides; liposomes; ESR

Sažetak
Adjuvants are compounds that are used to enhance the immune response of the host to an antigen. Among the others the peptidoglycan fragments were recognized as potent immunomodulators especially low molecular weight fragments that are mostly devoid of the toxic properties characteristic for large peptidoglycans, but still retain marked immunomodulating activity. Our studies concern the peptidoglycan monomer, GlcNAc-MurNAc-L-Ala-D-isoGlnmesoDAP-D-Ala-D-Ala (PGM), the natural compound originating from the Brevibacterium divaricatum peptidoglycan, its semisynthetic derivatives (Boc-Tyr-PGM and (Adamant-1-yl)-acetyl-PGM) and synthetic adamantyltripeptides D- and L-(adamant-2-yl)-Gly-L-Ala-D-isoGln. All the examined compounds are water-soluble, non-toxic and non-pyrogenic substances and their chemical structure has been completely defined. Biological activity of the prepared compounds has been continuously investigated and numerous papers were reported. In order to slow down their hydrolytic inactivation and thus achieve a prolonged biological action they are incorporated into liposomes. The interactions of incorporated compounds with phospholipids in liposomal bilayers were investigated by electron paramagnetic resonance spectroscopy. The spin labelled fatty acids, n-doxyl-stearic acids (n=5, 7, 16)were used to investigate the interaction of tested compounds with negatively charged multilamellar liposomes. The entrapment of the Boc-Tyr-PGM and adamantyltripeptides affected the motional properties of all spin labelled lipids, while the entrapment of PGM and (Adamant-1-yl)-acetyl-PGM had no effect.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Biotehnologija



POVEZANOST RADA


Projekti:
0098040
0021002

Ustanove:
Imunološki zavod d.d.,
Institut "Ruđer Bošković", Zagreb


Citiraj ovu publikaciju:

Frkanec, Ruža; Travaš, Dijana; Nöthig Laslo, Vesna; Mirosavljević Krunoslav; Krstanović, Marina; Vranešić, Branka; Tomašić, Jelka
The Effect of Chemical Structure and Stereochemistry on Interactions of Immunomodulatory Peptides with Lipid Bilayers in Liposomes // Peptides 2004. Proceedings of the 3^rd International and 28^th European Peptide Symposium / Flegel, Martin ; Fridkin, Mati ; Gilon, Chaim ; Slaninova, Jirina (ur.).
Geneva: Kenes International, 2005. str. 1115-1116 (poster, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)
Frkanec, R., Travaš, D., Nöthig Laslo, V., Mirosavljević Krunoslav, Krstanović, M., Vranešić, B. & Tomašić, J. (2005) The Effect of Chemical Structure and Stereochemistry on Interactions of Immunomodulatory Peptides with Lipid Bilayers in Liposomes. U: Flegel, M., Fridkin, M., Gilon, C. & Slaninova, J. (ur.)Peptides 2004. Proceedings of the 3^rd International and 28^th European Peptide Symposium.
@article{article, author = {Frkanec, Ru\v{z}a and Trava\v{s}, Dijana and N\"{o}thig Laslo, Vesna and Krstanovi\'{c}, Marina and Vrane\v{s}i\'{c}, Branka and Toma\v{s}i\'{c}, Jelka}, year = {2005}, pages = {1115-1116}, keywords = {peptidoglycan monomer, adamantyltripeptides, liposomes, ESR}, title = {The Effect of Chemical Structure and Stereochemistry on Interactions of Immunomodulatory Peptides with Lipid Bilayers in Liposomes}, keyword = {peptidoglycan monomer, adamantyltripeptides, liposomes, ESR}, publisher = {Kenes International}, publisherplace = {Prag, \v{C}e\v{s}ka Republika} }
@article{article, author = {Frkanec, Ru\v{z}a and Trava\v{s}, Dijana and N\"{o}thig Laslo, Vesna and Krstanovi\'{c}, Marina and Vrane\v{s}i\'{c}, Branka and Toma\v{s}i\'{c}, Jelka}, year = {2005}, pages = {1115-1116}, keywords = {peptidoglycan monomer, adamantyltripeptides, liposomes, ESR}, title = {The Effect of Chemical Structure and Stereochemistry on Interactions of Immunomodulatory Peptides with Lipid Bilayers in Liposomes}, keyword = {peptidoglycan monomer, adamantyltripeptides, liposomes, ESR}, publisher = {Kenes International}, publisherplace = {Prag, \v{C}e\v{s}ka Republika} }




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