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Transient Cellular Structures in Developing Corpus Callosum of the Human Brain

Jovanov-Milošević, Nataša; Benjak, Vesna; Kostović, Ivica
Transient Cellular Structures in Developing Corpus Callosum of the Human Brain // Collegium Antropologicum, 30 (2006), 2; 315-319 (međunarodna recenzija, članak, znanstveni)

Transient Cellular Structures in Developing Corpus Callosum of the Human Brain

Jovanov-Milošević, Nataša ; Benjak, Vesna ; Kostović, Ivica

Collegium Antropologicum (0350-6134) 30 (2006), 2; 315-319

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Human; development; commissural pathways; subcallosal zone

The corpus callosum connects two cerebral hemispheres as the most voluminous fiber system in the human brain. The developing callosal fibers originate from immature pyramidal neurons, grow through complex pathways and cross the midline using different substrates in transient fetal structures. We analyzed cellular structures in the human corpus callosum on postmortem brains from the age of 18 weeks post conception to adult, using glial fibrillary acidic protein, neuron-specific nuclear protein, and chondroitin sulphate immunocytochemistry. We found the presence of transient cellular structures, callosal septa, which divide major fiber bundles and ventrally merge with subcallosal zone forming grooves for callosal axons. The callosal septa are composed of glial fibrillary acidic protein reactive meshwork, neurones and the chondroitin sulphate immunoreactive extracellular matrix. The developmental window of prominence of the callosal septa is between 18-34 weeks post conception which corresponds to the period of most intensive growth of callosal axons in human. During the early postnatal period the callosal septa become thinner and shorter, lose their neuronal and chondroitin sulphate content. In conclusion, transient expression of neuronal, glial and extracellular, growing substrate in the callosal septa, as septa itself, indicates their role in guidance during intensive growth of callosal fibers in the human brain. These findings shed some light on the complex morphogenetic events during the growth of the corpus callosum and represent normative parameters necessary for studies of structural plasticity after perinatal lesions.

Izvorni jezik

Znanstvena područja
Temeljne medicinske znanosti


Projekt / tema

Medicinski fakultet, Zagreb

Časopis indeksira:

  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus