engleski

Influence of sodium cholate on the crystallization of calcium oxalate

Spontaneous, unseeded batch precipitation of calcium oxalate from aqueous solutions containing different concentrations of sodium cholate was followed at the conditions mimicking those in urine. Formation of calcium oxalate dihydrate in the systems where, in the absence of additive, calcium oxalate monohydrate is the only solid phase formed is clearly demonstrated. Depending on the structure of bile salt aqueous solutions, different influence on the overall crystallization yields is observed. Crystal growth inhibition in some systems could be attributed to the changes in the surface energy due to the adsorption of cholate on the surface of growing crystals. The retarding effect on crystal aggregation, observed in all investigated cholate-containing systems, might be of special importance from a biomedical point of view, since aggregation has been pointed out by many authors to be a crucial step in urolitihiasis.

ionic strength-solutions ; sodium cholate ; bile salts ; precipitation

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