engleski

Syntheses and enzymatic hydrolyses of acylated methyl alpa-D-mannopyranosides

Selective pivaloylations of methyl alpha-D-mannopyranosides under various reaction conditions have been studied. The structures of the products were established by 1-H-NMR spectroscopy and acetylation of partially pivaloylated compounds. The order of reactivity of hydroxyl groups was established and was found to be 6-OH>3-OH>2-OH>4-OH. The newly synthesized acylated monosaccharides were subjected to the hydrolysis by rabbit serum and esterases isolated from rabbit serum. Various degrees of regioselectivity were observed in these reactions, depending on the sugar structure

alpha-D-mannopyranosides; enzymatic deacylation; serum esterases; regioselectivity

nije evidentirano