engleski

Drug interactions of H2 - Receptor Antagonists Involving Cytochrome P450 (CYPs) Enzymes: From the Lab to the Clinic

This paper reviews the main steps in the research of the interactions of H2-receptor antagonist drugs with cytochrome P450 (CYP). Cimetidine, ranitidine and related compounds are used as examples. The results from in vitro studies are related to the observed clinically significant in vivo drug-drug and drug-chemical interactions. Uses of the in vitro results are discussed for the interpretation and possible prediction of drug-drug interactions, which may be important in developing new drugs. Other approach in the use of the in vitro data is to prevent the undesirable and toxic actions of drugs related to the catalytic activity of CYP enzymes. In the case of H2- receptor antagonists, the inhibition of the metabolic reactions due to the binding of the drugs with the enzymes was used to avoid side effects of co-administered drugs. The in vitro metabolic studies using recombinant human as well as animal CYP enzymes as model systems are now widely used when designing new drugs with improved therapeutic properties.

H2-receptor antagonists ; cytochromes P450 ; in vitro and in vivo studies ; drug-drug interactions

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