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Pregled bibliografske jedinice broj: 248962

Cut-off values for total serum immunoglobulin E between non-atopic and atopic children in north-west Croatia


Dodig, Slavica; Richter, Darko; Benko, Bojan; Živčić, Jadranka; Raos, Miljenko; Nogalo, Boro; Čepelak, Ivana; Dodig, Matko
Cut-off values for total serum immunoglobulin E between non-atopic and atopic children in north-west Croatia // Clinical Chemistry and Laboratory Medicine, 44 (2006), 5; 639-647 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 248962 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cut-off values for total serum immunoglobulin E between non-atopic and atopic children in north-west Croatia

Autori
Dodig, Slavica ; Richter, Darko ; Benko, Bojan ; Živčić, Jadranka ; Raos, Miljenko ; Nogalo, Boro ; Čepelak, Ivana ; Dodig, Matko

Izvornik
Clinical Chemistry and Laboratory Medicine (1434-6621) 44 (2006), 5; 639-647

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ukupni IgE; referentne vrijednosti; specifični IgE; preosjetljivost; dijete; ROC krivulja
(total IgE; reference values; specific IgE sensitization; child; ROC curve)

Sažetak
Background: The aim of this study was to determine cut-off values for total serum immunoglobulin E (IgE) between non-atopic and atopic children with respiratory symptoms. Children of 0-16 years of age were evaluated for respiratory symptoms of >4-week duration. Methods: Children were divided into two groups: non-atopic children (n=3355) who were non-IgE-sensitized with undetectable allergen-specific IgE (<0.35 kIU(A)/L), and atopic children (n=4620) who were sensitized to >/=1 allergens (specific IgE >/=0.35 kIU(A)/L). Upper and lower centiles were determined and cut-off values calculated using receiver operating characteristic (ROC) analysis. Results: Serum total IgE increased with age in both groups, although at a variable level and rate, and reached a plateau at 9 and 10 years in non-atopic and atopic children, respectively. Atopic children had on average 14-fold higher serum total IgE compared to non-atopic children. In both groups, the median was lower than the corresponding mean and the distribution skewness was always positive (group I, 0.87 ; group II, 0.91). In almost all age groups, the 95th percentile for non-atopic children corresponded to the calculated cut-off values, whereas the 10th percentile for atopic children corresponded to the respective cut-off values only until the age of 8 years, after which greater differences between the cut-off values and the 10th percentile were recorded. Cut-off values for total serum IgE in children up to 16 years were determined with diagnostic sensitivity, specificity and area under the ROC curve of 96%, 91% and 0.950, respectively. Conclusions: The 95th percentile for total IgE in non-atopic children and the 10th percentile in atopic children could be taken as cut-off values in children up to 8 years of age, after which significant percentile discrepancies between non-atopic and atopic children were recorded. Since atopic subjects show a more irregular centile distribution, cut-off values are best determined by ROC analysis.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

Napomena
Rad donosi referentne vrijednosti koncentracije ukupnoga IgE u serumu djece od 0 do 16 godina u Hrvatskoj. Izrađen je u Referentnom centru Ministarstva zdravstva RH za kliničku alergologiju djece, Dječja bolnica Srebrnjak



POVEZANOST RADA


Projekti:
0277001
0006631

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Dječja bolnica Srebrnjak


Citiraj ovu publikaciju:

Dodig, Slavica; Richter, Darko; Benko, Bojan; Živčić, Jadranka; Raos, Miljenko; Nogalo, Boro; Čepelak, Ivana; Dodig, Matko
Cut-off values for total serum immunoglobulin E between non-atopic and atopic children in north-west Croatia // Clinical Chemistry and Laboratory Medicine, 44 (2006), 5; 639-647 (međunarodna recenzija, članak, znanstveni)
Dodig, S., Richter, D., Benko, B., Živčić, J., Raos, M., Nogalo, B., Čepelak, I. & Dodig, M. (2006) Cut-off values for total serum immunoglobulin E between non-atopic and atopic children in north-west Croatia. Clinical Chemistry and Laboratory Medicine, 44 (5), 639-647.
@article{article, year = {2006}, pages = {639-647}, keywords = {ukupni IgE, referentne vrijednosti, specifi\v{c}ni IgE, preosjetljivost, dijete, ROC krivulja}, journal = {Clinical Chemistry and Laboratory Medicine}, volume = {44}, number = {5}, issn = {1434-6621}, title = {Cut-off values for total serum immunoglobulin E between non-atopic and atopic children in north-west Croatia}, keyword = {ukupni IgE, referentne vrijednosti, specifi\v{c}ni IgE, preosjetljivost, dijete, ROC krivulja} }
@article{article, year = {2006}, pages = {639-647}, keywords = {total IgE, reference values, specific IgE sensitization, child, ROC curve}, journal = {Clinical Chemistry and Laboratory Medicine}, volume = {44}, number = {5}, issn = {1434-6621}, title = {Cut-off values for total serum immunoglobulin E between non-atopic and atopic children in north-west Croatia}, keyword = {total IgE, reference values, specific IgE sensitization, child, ROC curve} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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