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Pregled bibliografske jedinice broj: 248016

Downstream targets of nm23-H1: Gene expression profiling of CAL 27 cells using DNA microarray


Herak Bosnar, Maja; Bago, Ružica; Gall-Trošelj, Koraljka; Streichert, Thomas; Pavelić, Jasminka
Downstream targets of nm23-H1: Gene expression profiling of CAL 27 cells using DNA microarray // Molecular Carcinogenesis, 45 (2006), 8; 627-633 (međunarodna recenzija, članak, znanstveni)


Naslov
Downstream targets of nm23-H1: Gene expression profiling of CAL 27 cells using DNA microarray

Autori
Herak Bosnar, Maja ; Bago, Ružica ; Gall-Trošelj, Koraljka ; Streichert, Thomas ; Pavelić, Jasminka

Izvornik
Molecular Carcinogenesis (0899-1987) 45 (2006), 8; 627-633

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Nm23-H1; DNA microarray; oral squamous cell carcinoma

Sažetak
The human nm23-H1 was discovered as a tumor metastasis suppressor based on its reduced expression in melanoma cell lines with low vs. high metastatic potential. It encodes for one of two subunits of the nucleoside-diphosphate kinase. Besides its role in the maintenance of the cells NTP pool, nm23 plays a key role in different cellular processes. The role of nm23-H1 in these processes still has to be elucidated. Our goal was to identify Nm23-H1 downstream targets by subjecting Nm23-H1 overexpressing CAL 27 cells (oral squamous cell carcinoma) to microarray analysis. The genes with changed expression patterns could be clustered into several groups: TGF signaling pathway, cell adhesion, invasion and motility, proteasome machinery, cell cycle, epithelial structural and related molecules and others. Based on the expression patterns observed we presume that nm23-H1 might have a role in oral squamous cell carcinomas, which should be confirmed by future experiments.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
0098092
0098095
0101023

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE