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Pregled bibliografske jedinice broj: 247985

Angiogenesis and Ewing sarcoma--relationship to pulmonary metastasis and survival


Mikulić, Danko; Ilić, Ivana; Ćepulić, Mladen; Stepan Giljević, Jasminka; Orlić, Dubravko; Župančić, Božidar; Fattorini, Ivan; Seiwerth, Sven
Angiogenesis and Ewing sarcoma--relationship to pulmonary metastasis and survival // Journal of Pediatric Surgery, 41 (2006), 3; 524-529 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 247985 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Angiogenesis and Ewing sarcoma--relationship to pulmonary metastasis and survival

Autori
Mikulić, Danko ; Ilić, Ivana ; Ćepulić, Mladen ; Stepan Giljević, Jasminka ; Orlić, Dubravko ; Župančić, Božidar ; Fattorini, Ivan ; Seiwerth, Sven

Izvornik
Journal of Pediatric Surgery (0022-3468) 41 (2006), 3; 524-529

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Ewing sarcoma; Angiogenesis; Microvessel density; von Willebrand factor

Sažetak
BACKGROUND/PURPOSE: Intratumoral angiogenesis quantified by microvessel density (MVD) has been shown to be a strong prognostic indicator in a number of malignant tumors. Its association with prognosis in Ewing sarcoma has not been previously studied. The aim of our study was to investigate the relationship between angiogenesis and clinical outcome in Ewing sarcoma. METHODS: Twenty-seven patients with Ewing sarcoma were included in a retrospective immunohistochemical study. Sections from diagnostic biopsies were immunostained using anti-von Willebrand factor antibody and microvessels were counted at 400x magnification on three microscopic fields per patient. Microvessel density was correlated with overall and disease-free survival as a continuous variable using univariate regression analysis and as a dichotomous variable by Kaplan-Meier and log-rank analysis. Correlation between clinicopathologic variables and the degree of angiogenesis was tested using chi(2) test. RESULTS: Increasing MVD was not confirmed to be a poor prognostic factor in univariate analysis. Also, statistically significant difference was not found in overall survival or disease-free survival between patients with high (>31.6 vessels per field) and low (<or=31.6 vessels per field) microvessel counts. Finally, there was no difference regarding the metastatic rate between patients with high and low microvessel counts. CONCLUSIONS: Our results did not confirm increasing angiogenesis quantified by MVD to be predictive of prognosis or pulmonary metastasis in Ewing sarcoma. The diffuse pattern of distribution of microvessels found in Ewing sarcoma may be responsible for the observed lack of prognostic significance of angiogenesis. Future work is required to assess the prognostic importance of MVD in this disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
0108238

Ustanove:
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju

Mikulić, Danko; Ilić, Ivana; Ćepulić, Mladen; Stepan Giljević, Jasminka; Orlić, Dubravko; Župančić, Božidar; Fattorini, Ivan; Seiwerth, Sven
Angiogenesis and Ewing sarcoma--relationship to pulmonary metastasis and survival // Journal of Pediatric Surgery, 41 (2006), 3; 524-529 (međunarodna recenzija, članak, znanstveni)
Mikulić, D., Ilić, I., Ćepulić, M., Stepan Giljević, J., Orlić, D., Župančić, B., Fattorini, I. & Seiwerth, S. (2006) Angiogenesis and Ewing sarcoma--relationship to pulmonary metastasis and survival. Journal of Pediatric Surgery, 41 (3), 524-529.
@article{article, year = {2006}, pages = {524-529}, keywords = {Ewing sarcoma, Angiogenesis, Microvessel density, von Willebrand factor}, journal = {Journal of Pediatric Surgery}, volume = {41}, number = {3}, issn = {0022-3468}, title = {Angiogenesis and Ewing sarcoma--relationship to pulmonary metastasis and survival}, keyword = {Ewing sarcoma, Angiogenesis, Microvessel density, von Willebrand factor} }
@article{article, year = {2006}, pages = {524-529}, keywords = {Ewing sarcoma, Angiogenesis, Microvessel density, von Willebrand factor}, journal = {Journal of Pediatric Surgery}, volume = {41}, number = {3}, issn = {0022-3468}, title = {Angiogenesis and Ewing sarcoma--relationship to pulmonary metastasis and survival}, keyword = {Ewing sarcoma, Angiogenesis, Microvessel density, von Willebrand factor} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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