Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Angiogenesis and Ewing sarcoma--relationship to pulmonary metastasis and survival (CROSBI ID 123507)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Mikulić, Danko ; Ilić, Ivana ; Ćepulić, Mladen ; Stepan Giljević, Jasminka ; Orlić, Dubravko ; Župančić, Božidar ; Fattorini, Ivan ; Seiwerth, Sven Angiogenesis and Ewing sarcoma--relationship to pulmonary metastasis and survival // Journal of pediatric surgery, 41 (2006), 3; 524-529-x

Podaci o odgovornosti

Mikulić, Danko ; Ilić, Ivana ; Ćepulić, Mladen ; Stepan Giljević, Jasminka ; Orlić, Dubravko ; Župančić, Božidar ; Fattorini, Ivan ; Seiwerth, Sven

engleski

Angiogenesis and Ewing sarcoma--relationship to pulmonary metastasis and survival

BACKGROUND/PURPOSE: Intratumoral angiogenesis quantified by microvessel density (MVD) has been shown to be a strong prognostic indicator in a number of malignant tumors. Its association with prognosis in Ewing sarcoma has not been previously studied. The aim of our study was to investigate the relationship between angiogenesis and clinical outcome in Ewing sarcoma. METHODS: Twenty-seven patients with Ewing sarcoma were included in a retrospective immunohistochemical study. Sections from diagnostic biopsies were immunostained using anti-von Willebrand factor antibody and microvessels were counted at 400x magnification on three microscopic fields per patient. Microvessel density was correlated with overall and disease-free survival as a continuous variable using univariate regression analysis and as a dichotomous variable by Kaplan-Meier and log-rank analysis. Correlation between clinicopathologic variables and the degree of angiogenesis was tested using chi(2) test. RESULTS: Increasing MVD was not confirmed to be a poor prognostic factor in univariate analysis. Also, statistically significant difference was not found in overall survival or disease-free survival between patients with high (>31.6 vessels per field) and low (<or=31.6 vessels per field) microvessel counts. Finally, there was no difference regarding the metastatic rate between patients with high and low microvessel counts. CONCLUSIONS: Our results did not confirm increasing angiogenesis quantified by MVD to be predictive of prognosis or pulmonary metastasis in Ewing sarcoma. The diffuse pattern of distribution of microvessels found in Ewing sarcoma may be responsible for the observed lack of prognostic significance of angiogenesis. Future work is required to assess the prognostic importance of MVD in this disease.

Ewing sarcoma; Angiogenesis; Microvessel density; von Willebrand factor

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

41 (3)

2006.

524-529-x

objavljeno

0022-3468

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost