Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 247799

Ubiquitin-positive inclusions predominate in 48 cases of frontotemporal lobar degeneration.


Liščić, Rajka; Tenenholz Grinberg, Lea; Cairns, Nigel J; Morris, John C.
Ubiquitin-positive inclusions predominate in 48 cases of frontotemporal lobar degeneration. // Growth and Death in the Nervous System / Aguzzi, Adriano ; Glatzel, Markus (ur.).
Zurich: Institute for Neuropathology, Zurich, 2006. str. 25-25 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 247799 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Ubiquitin-positive inclusions predominate in 48 cases of frontotemporal lobar degeneration.

Autori
Liščić, Rajka ; Tenenholz Grinberg, Lea ; Cairns, Nigel J ; Morris, John C.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Growth and Death in the Nervous System / Aguzzi, Adriano ; Glatzel, Markus - Zurich : Institute for Neuropathology, Zurich, 2006, 25-25

Skup
Swiss Society of Neuropathology, XXI International Winter Meeting in St. Moritz

Mjesto i datum
St. Moritz, Švicarska, 22-26.03.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Frontotemporal lobar degeneration; Ubiquitin

Sažetak
Backgroud: The frontotemporal lobar degenerations (FTLDs) are clinically and neuropathologically heterogeneous and may account for 5-10% of dementias. Advances in immunohistochemistry, biochemistry, and genetics of FTLDs have helped to define this pathological spectrum of FTLDs. Aims: To determine the pathological spectrum and frequency of FTLDs in a cohort of individuals from Washington University Alzheimers Disease Research Center (WUADRC). Methods: Review of 833 prospectively assesses dementia cases between 1988 and 2005 at the WUADRC and selection of cases with a neuropathological diagnosis of FTLD according to established and other neuropathological criteria. Brain tissue was processed and blocks taken according to the established protocols of the WUADRC Neuropathology Core. Immunohistochemistry was performed on selected areas against the following peptides or proteins: ß-amyloid, phosphorylated tau, α -synuclein, ubiquitin, α -internexin, and valosin-containing protein. Results: Of 48 FTLD cases (5.7% of 833 cases), 14 were classified as containing protein tau: Pick’ s disease (n=2), corticobasal degeneration (n=9), argyrophilic grain disease (AGD, n=1), and frontotemporal dementia with parkinsonism linked to chromosome 17 (n=2). However, the majority of cases were characterized by tau-negative inclusions: FTLD with ubiquitin inclusions (FTLD-U) (n=24). One case had valosin-containing protein inclusions, also called inclusion body myositis with Paget disease and frontotemporal dementia (IBMPFD) ; or none, also called dementia lacking distinctive histopathology (DLDH, n=9). Conclusion: FTLD-U is the most frequent FTLD in this series (50%). Less common entities not typically included such as IBMPFD, AGD may also have the clinical phenotype of FTLD and should be considered as part of the neuropathological spectrum of FTLDs.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
0022009

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Profili:

Avatar Url Rajka Liščić (autor)


Citiraj ovu publikaciju:

Liščić, Rajka; Tenenholz Grinberg, Lea; Cairns, Nigel J; Morris, John C.
Ubiquitin-positive inclusions predominate in 48 cases of frontotemporal lobar degeneration. // Growth and Death in the Nervous System / Aguzzi, Adriano ; Glatzel, Markus (ur.).
Zurich: Institute for Neuropathology, Zurich, 2006. str. 25-25 (poster, međunarodna recenzija, sažetak, znanstveni)
Liščić, R., Tenenholz Grinberg, L., Cairns, N. & Morris, J. (2006) Ubiquitin-positive inclusions predominate in 48 cases of frontotemporal lobar degeneration.. U: Aguzzi, A. & Glatzel, M. (ur.)Growth and Death in the Nervous System.
@article{article, author = {Li\v{s}\v{c}i\'{c}, Rajka and Tenenholz Grinberg, Lea and Cairns, Nigel J and Morris, John C.}, year = {2006}, pages = {25-25}, keywords = {Frontotemporal lobar degeneration, Ubiquitin}, title = {Ubiquitin-positive inclusions predominate in 48 cases of frontotemporal lobar degeneration.}, keyword = {Frontotemporal lobar degeneration, Ubiquitin}, publisher = {Institute for Neuropathology, Zurich}, publisherplace = {St. Moritz, \v{S}vicarska} }
@article{article, author = {Li\v{s}\v{c}i\'{c}, Rajka and Tenenholz Grinberg, Lea and Cairns, Nigel J and Morris, John C.}, year = {2006}, pages = {25-25}, keywords = {Frontotemporal lobar degeneration, Ubiquitin}, title = {Ubiquitin-positive inclusions predominate in 48 cases of frontotemporal lobar degeneration.}, keyword = {Frontotemporal lobar degeneration, Ubiquitin}, publisher = {Institute for Neuropathology, Zurich}, publisherplace = {St. Moritz, \v{S}vicarska} }




Contrast
Increase Font
Decrease Font
Dyslexic Font