engleski

Human papillomavirus types 52 and 58 among Croatian wome

Infection with high-risk human papillomavirus (HR HPV) has been implicated as the main and sole cause of cervical cancer. In Europe HR HPV 18, 33 and 31 are the most frequently found after HPV 16 that account for more than 60% of cases (1). HR HPV 52 and 58 are less frequent in Europe but not uncommon worldwide, especially in Asia. The aim of this study was to evaluate the prevalence of HPV 52 and 58 among Croatian women. Thus, women with cytological abnormalities, aged 15 to 78 years, were included for HPV DNA detection by polymerase chain reaction (PCR) using two sets of universal primers (MY09/MY11 and L1C1/L1C2) as previously described (2). HPV types 6/11, 16, 18, 31, 33, 52 and 58 were determined by type-specific primers directed PCR. Out of 2, 241 specimens, 60.9 and 39.1% was HPV DNA positive and negative, respectively. As a sole infection the most frequently observed type was HPV 16 in 11.4% cases. The second most frequent HR type was HPV 31 found in 5.5% cases. HR HPV 18, 33 and 52 were found in almost equal proportions in 2.4, 2.7 and 2.6%, respectively. HR HPV 58 was the less frequently found in 1% cases. Additionally, LR HPV 6/11 and multiple HPV infections were both found in 5.8% cases, respectively. Among HPV DNA positive samples 23.7% samples remained untyped. Our results indicate that HPV 16 is the most common, while HPV 31 is the second most common HR HPV type among Croatian women ; HPV 52 is as frequent as HPV 18 and 33 that are the third most common HR HPV ; HPV 58 seems uncommon HR HPV type. According to our finding all HPV positive abnormal cervical specimens in Croatia should be typed for at least HR HPV 16, 18, 31, 33 and 52. (1)Clifford GM et al. Br J Cancer 2003 ; 88: 63-73. (2)Grce M et al., Anticancer Res 2001 ; 21: 579-584.

Human papillomavirus

nije evidentirano