engleski

Role of impaired angiotensin II (ANG II) modulation and increased oxidative stress in impaired vascular relaxation in middle cerebral arteries (MCA) of Dahl salt sensitive (SS) rats on low salt (LS) diet

This study investigated the role of impaired angiotensin II (Ang II) modulation in contributing to reduced vascular relaxation in isolated middle cerebral arteries (MCA) of normotensive Dahl salt-sensitive (SS) rats maintained on low salt (LS) diet (0.4% NaCl) for 9 to 10 weeks.These data indicate that exposure to chronically low Ang II levels leads to impaired vascular relaxation in SS rats, even when the animals are on LS diet and normotensive. This impaired relaxation appears to be mediated by increased levels of oxidative stress in the arteries.

oxidative stress; angiotensin II; hypertension; consomic rats; salt-sensitivity

Hypertension 44(4):543-544, 2004 P148. ISSN 0194-911X