Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 246718

Growth hormone and insulin growth factor-I levels in plasma and cerebrospinal fluid of patients with multiple sclerosis


Poljaković, Zdravka; Zurak, Niko; Brinar, Vesna V.; Koršić, Mirko; Bašić, Silvio; Hajnšek, Sanja
Growth hormone and insulin growth factor-I levels in plasma and cerebrospinal fluid of patients with multiple sclerosis // Clinical neurology and neurosurgery (Dutch-Flemish ed.), 108 (2006), 3; 255-258 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 246718 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Growth hormone and insulin growth factor-I levels in plasma and cerebrospinal fluid of patients with multiple sclerosis

Autori
Poljaković, Zdravka ; Zurak, Niko ; Brinar, Vesna V. ; Koršić, Mirko ; Bašić, Silvio ; Hajnšek, Sanja

Izvornik
Clinical neurology and neurosurgery (Dutch-Flemish ed.) (0303-8467) 108 (2006), 3; 255-258

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Multiple sclerosis; Growth factors; Growth hormone; Cerebrospinal fluid

Sažetak
Multiple sclerosis (MS) has several clinically different forms. Whereas the illness progresses slowly in most of the patients, 10% have an aggressively progressive course with fatal outcome without signs of remyelination capability. The process of remyelination depends on numerous interactive factors, including the presence of various growth factors, the most important of which in the adult is insulin growth factor-I (IGF-I). On the other hand, the most powerful postnatal regulator of IGF-I is growth hormone (GH), which also acts as a neuroprotective and an antiapoptotic agent, and has direct influence on myelination. Levels of these growth factors have never been examined in the cerebrospinal fluid (CSF) of patients with MS. The levels of IGF-I and GH were measured in serum and CSF of 46 MS patients and compared with those of 49 patients with no evidence of demyelinating disease. The only positive finding was a deficiency of GH in the CSF of MS patients. The possible implications of those findings in the etiopathogenesis of MS will be discussed.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Rad je prezentiran na skupu 3rd Dubrovnik International Conference on Multiple Sclerosis ; održanom od 19.-21.05.2005.g., Dubrovnik, Hrvatska ; Vesna V. Brinar, Charles M. Poser (ur.).



POVEZANOST RADA


Projekt / tema
0108042

Ustanove
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Poljaković, Zdravka; Zurak, Niko; Brinar, Vesna V.; Koršić, Mirko; Bašić, Silvio; Hajnšek, Sanja
Growth hormone and insulin growth factor-I levels in plasma and cerebrospinal fluid of patients with multiple sclerosis // Clinical neurology and neurosurgery (Dutch-Flemish ed.), 108 (2006), 3; 255-258 (međunarodna recenzija, članak, znanstveni)
Poljaković, Z., Zurak, N., Brinar, V., Koršić, M., Bašić, S. & Hajnšek, S. (2006) Growth hormone and insulin growth factor-I levels in plasma and cerebrospinal fluid of patients with multiple sclerosis. Clinical neurology and neurosurgery (Dutch-Flemish ed.), 108 (3), 255-258.
@article{article, year = {2006}, pages = {255-258}, keywords = {Multiple sclerosis, Growth factors, Growth hormone, Cerebrospinal fluid}, journal = {Clinical neurology and neurosurgery (Dutch-Flemish ed.)}, volume = {108}, number = {3}, issn = {0303-8467}, title = {Growth hormone and insulin growth factor-I levels in plasma and cerebrospinal fluid of patients with multiple sclerosis}, keyword = {Multiple sclerosis, Growth factors, Growth hormone, Cerebrospinal fluid} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE