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Pregled bibliografske jedinice broj: 24443

Antiproliferative effects of new synthetise DNA-intercalators


Steiner-Biočić, Ivka; Glavaš-Obrovac, Ljubica, Pavelić, Krešimir
Antiproliferative effects of new synthetise DNA-intercalators // FEBS 96, 24th meeting of the federation of european biochemical societies
Barcelona: FEBS, 1996. (poster, međunarodna recenzija, sažetak, znanstveni)


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Naslov
Antiproliferative effects of new synthetise DNA-intercalators

Autori
Steiner-Biočić, Ivka ; Glavaš-Obrovac, Ljubica, Pavelić, Krešimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
FEBS 96, 24th meeting of the federation of european biochemical societies / - Barcelona : FEBS, 1996

Skup
FEBS 96, 24th meeting of the federation of european biochemical societies

Mjesto i datum
Barcelona, Španjolska, 07.06.1996. - 12.06.1996

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
DNA- intecalators; tumor cell lines

Sažetak
We have investigated the antiproliferative and cytotoxic effects of planar 4,9-dimethyl-4,9 diazapyrenium and 2,4,7,9-tetramethyl-4,9 diazapyrenium hydrogensulphates against human malignat MiaPaCa2 (pancreatic carcinoma), Hep2 (laryngeal carcinoma9 and human normal fibroblasts (WI 38) cell lines. The tested compounds were found to be very potent to inhibiting the growth of the treated cell lines. Treatment with molar concentration of substances (10-4 - 10-7 M) was capable of causong 50% and more growth inhibition. The morphological changes on treated cells were observed. The identification and the appearance of chromatin aggregation leads us to assume the apoptosis or programed cell death of investigated tumor cell lines induced by the applying planar cyclic compounds.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
127009

Ustanove:
Klinički bolnički centar Osijek


Citiraj ovu publikaciju:

Steiner-Biočić, Ivka; Glavaš-Obrovac, Ljubica, Pavelić, Krešimir
Antiproliferative effects of new synthetise DNA-intercalators // FEBS 96, 24th meeting of the federation of european biochemical societies
Barcelona: FEBS, 1996. (poster, međunarodna recenzija, sažetak, znanstveni)
Steiner-Biočić, I. & Glavaš-Obrovac, Ljubica, Pavelić, Krešimir (1996) Antiproliferative effects of new synthetise DNA-intercalators. U: FEBS 96, 24th meeting of the federation of european biochemical societies.
@article{article, author = {Steiner-Bio\v{c}i\'{c}, Ivka}, year = {1996}, pages = {126}, keywords = {DNA- intecalators, tumor cell lines}, title = {Antiproliferative effects of new synthetise DNA-intercalators}, keyword = {DNA- intecalators, tumor cell lines}, publisher = {FEBS}, publisherplace = {Barcelona, \v{S}panjolska} }
@article{article, author = {Steiner-Bio\v{c}i\'{c}, Ivka}, year = {1996}, pages = {126}, keywords = {DNA- intecalators, tumor cell lines}, title = {Antiproliferative effects of new synthetise DNA-intercalators}, keyword = {DNA- intecalators, tumor cell lines}, publisher = {FEBS}, publisherplace = {Barcelona, \v{S}panjolska} }




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