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Pregled bibliografske jedinice broj: 244348

Effects of intrahippocampal injection of kainic acid on eeg and gross behavior in rats


Križ, Jasna; Župan, Gordana; Križ, Mladen; Simonić, Ante
Effects of intrahippocampal injection of kainic acid on eeg and gross behavior in rats // Acta Facultatis Medicae Fluminensis, 19 (1994), 13-18 (međunarodna recenzija, članak, znanstveni)


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Naslov
Effects of intrahippocampal injection of kainic acid on eeg and gross behavior in rats

Autori
Križ, Jasna ; Župan, Gordana ; Križ, Mladen ; Simonić, Ante

Izvornik
Acta Facultatis Medicae Fluminensis (0065-1206) 19 (1994); 13-18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
kainic acid; epileptic seizures; EEG; frequency analysis; rat

Sažetak
Kainic acid (KA) is an excitatory glutaminergic agonist that induces epileptic seizures. The purpose of this study was to record EEG activity and the behavioral pattern changes after an intrahippocampal KA administration. Experiments were performed on adult Wistar rats. The animals were anesthetized and placed in a stereotaxic apparatus. Surface screw electrodes were placed over the frontal and parietal cortex. KA was administrated into the left dorsal hippocampus. The EEG activity was recorded in a basal conditions and 5, 10, 15, 30 and 60 minutes after the KA application. During this period complex behavioral pattern was also observed. EEG samples were digitized and subjected to computerized frequency analysis. The KA-induced excitatory changes in EEG activity were followed by complex behavioral syndrome that lasted for several hours. It has been concluded that intrahippocampal injection of kainate may be a useful experimental model for investigations of partial seizures with complex simptomatology (temporal lobe seizures disorders).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
3-01-433

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Mladen Križ (autor)

Avatar Url Ante Simonić (autor)

Avatar Url Gordana Župan (autor)

Avatar Url Jasna Križ (autor)


Citiraj ovu publikaciju:

Križ, Jasna; Župan, Gordana; Križ, Mladen; Simonić, Ante
Effects of intrahippocampal injection of kainic acid on eeg and gross behavior in rats // Acta Facultatis Medicae Fluminensis, 19 (1994), 13-18 (međunarodna recenzija, članak, znanstveni)
Križ, J., Župan, G., Križ, M. & Simonić, A. (1994) Effects of intrahippocampal injection of kainic acid on eeg and gross behavior in rats. Acta Facultatis Medicae Fluminensis, 19, 13-18.
@article{article, year = {1994}, pages = {13-18}, keywords = {kainic acid, epileptic seizures, EEG, frequency analysis, rat}, journal = {Acta Facultatis Medicae Fluminensis}, volume = {19}, issn = {0065-1206}, title = {Effects of intrahippocampal injection of kainic acid on eeg and gross behavior in rats}, keyword = {kainic acid, epileptic seizures, EEG, frequency analysis, rat} }
@article{article, year = {1994}, pages = {13-18}, keywords = {kainic acid, epileptic seizures, EEG, frequency analysis, rat}, journal = {Acta Facultatis Medicae Fluminensis}, volume = {19}, issn = {0065-1206}, title = {Effects of intrahippocampal injection of kainic acid on eeg and gross behavior in rats}, keyword = {kainic acid, epileptic seizures, EEG, frequency analysis, rat} }

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  • Scopus


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