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Piracetam and oxiracetam prevent hypoxia-induced impairment of passive avoidance behavior in rats

The influence of nootropic drugs, piracetam and oxiracetam, on passive avoidance behavior in intact and hypoxia-exposed rats was examined. Various doses of the drugs tested were injected 60 minutes before the learning trial. Some of the animals were exposed to controlled hypoxic conditions immediately after the learning trial response had been acquired. Twenty four hours later, the passive avoidance retention test was performed. Hypoxia was found to cause a statistically significant impairment in the retention of passive avoidance response. Piracetam and oxiracetam did not influence passive avoidance behavior in intact animals. On the contrary, all tested doses of the substances examined significantly improved the learning ability in the rats in which cognitive deficiency was caused by hypoxia. It was also found that the effect of the drugs tested were dose-dependent. The authors suggest that piracetam and oxiracetam could be used as a therapeutic agents for the treatment of cognitive disturbances due to cerebral hypoxia.

cerebral hypoxia; nootropics; passive avoidance behavior; rat

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