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Potential therapeutic targets in Alzheimer's disease


Simonić, Ante; Župan, Gordana
Potential therapeutic targets in Alzheimer's disease // Acta Pharmaceutica, 47 (1997), 1; 1-7 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
Potential therapeutic targets in Alzheimer's disease

Autori
Simonić, Ante ; Župan, Gordana

Izvornik
Acta Pharmaceutica (1330-0075) 47 (1997), 1; 1-7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Alzheimer's disease; therapy; cholinergic neurotransmission; excitatory amino acid; Ca2+; free radicals beta amyloid; tau protein; neurotrophic factors

Sažetak
Alzheimer's disease (AD) is a common, heterogeneous age related degenerative dementia of unknown etiology and multifactorial origin. It is characterized by a progressive loss of intellectual function. At present there is no available treatment that can cure, reverse or stop progression of AD. The basic strategies for potentially effective treatment for AD are: compensation of cholinergic deficit, blockade of excitatory amino acid receptor overstimulation, blockade of excessive influx of extracellular Ca2+, decrease of free acids and free radicals accumulation, blockade of beta amyloid deposition and hyperphosphorylation of tau protein, and apoptosis prevention.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
3-01-433

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Ante Simonić (autor)

Avatar Url Gordana Župan (autor)


Citiraj ovu publikaciju

Simonić, Ante; Župan, Gordana
Potential therapeutic targets in Alzheimer's disease // Acta Pharmaceutica, 47 (1997), 1; 1-7 (međunarodna recenzija, pregledni rad, znanstveni)
Simonić, A. & Župan, G. (1997) Potential therapeutic targets in Alzheimer's disease. Acta Pharmaceutica, 47 (1), 1-7.
@article{article, year = {1997}, pages = {1-7}, keywords = {Alzheimer's disease, therapy, cholinergic neurotransmission, excitatory amino acid, Ca2+, free radicals beta amyloid, tau protein, neurotrophic factors}, journal = {Acta Pharmaceutica}, volume = {47}, number = {1}, issn = {1330-0075}, title = {Potential therapeutic targets in Alzheimer's disease}, keyword = {Alzheimer's disease, therapy, cholinergic neurotransmission, excitatory amino acid, Ca2+, free radicals beta amyloid, tau protein, neurotrophic factors} }
@article{article, year = {1997}, pages = {1-7}, keywords = {Alzheimer's disease, therapy, cholinergic neurotransmission, excitatory amino acid, Ca2+, free radicals beta amyloid, tau protein, neurotrophic factors}, journal = {Acta Pharmaceutica}, volume = {47}, number = {1}, issn = {1330-0075}, title = {Potential therapeutic targets in Alzheimer's disease}, keyword = {Alzheimer's disease, therapy, cholinergic neurotransmission, excitatory amino acid, Ca2+, free radicals beta amyloid, tau protein, neurotrophic factors} }

Časopis indeksira:


  • Scopus





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