engleski

Concentration-dependent effects of peroxovanadium compound bpV (phen) on PC12 cell survival survival

Peroxovanadium compounds are potent insulinomimetic agents and protein tyrosine phosphatase inhibitors. In this study we have examined the potential toxicity of peroxovanadium complex bpV (phen) on rat pheochromocytoma PC12 cells, and we have explored the mechanism by which this compound influences cell survival and/or death. BpV (phen) exerted bimodal effect on PC12 cells: survival-enhancing effect at lower and death-inducing effect at higher micromolar concentrations. 1 and 3  M bpV (phen) intensely induced ERK activation. In contrast, 10 and 100  M bpV (phen) stimulated strong and sustained JNK and p38 MAPK activation as well as caspase-3 activation that preceded bpV (phen)-induced apoptotic cell death. We suggest that bpV (phen) might exert its action on PC12 cell survival by modulation of MAPKs and caspase-3 activation.

peroxovanadium; MAPK; caspase; apoptosis; PC12 cells

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