Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 243581

In vivo bidirectional regulation of mouse natural killer (NK) cell cytotoxic activities by Leu-enkephalin: Reversibility by naloxone


Gabrilovac, Jelka; Antica, Mariastefania; Osmak, Maja
In vivo bidirectional regulation of mouse natural killer (NK) cell cytotoxic activities by Leu-enkephalin: Reversibility by naloxone // Life sciences, 50 (1992), 1; 29-37 doi:10.1016/0024-3205(92)90194-T (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 243581 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
In vivo bidirectional regulation of mouse natural killer (NK) cell cytotoxic activities by Leu-enkephalin: Reversibility by naloxone
(In vivo biderectional regulation of mouse natural killer (NK) cell cytotoxic activities by Leu-Enkephalin: Reversibility by naloxone)

Autori
Gabrilovac, Jelka ; Antica, Mariastefania ; Osmak, Maja

Izvornik
Life sciences (0024-3205) 50 (1992), 1; 29-37

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Leu-enkephalin ; bidirectional immunomodulation ; NK-cells ; ADCC ; opioid receptors

Sažetak
Intraperitoneal injection of Leu-enkephalin (LENK, 10 or 7.5 mg/kg) induced bidirectional modulation of natural cytotoxic activities in spleens of CBA mice (suppression followed by enhancement). NK-cytotoxic activity was more affected than the ADCC. Early suppression of NK activity could be reversed by 4 x M excess of naloxone injected 20 min before LENK, suggesting that the suppression was mediated by opioid receptors. Subsequent increase of NK activity could not be abrogated by naloxone, at least not completely. Naloxone itself decreased NK activity 12 hours after treatment, but enhanced ADCC at 24 and 48 hours. This increase was abrogated by LENK. In addition to functional alterations, LENK also induced phenotypic changes of spleen cells, i.e. a decrease in the percentage of asialo-GM-1+ cells 24 hours posttreatment. There was no correlation between LENK-induced alterations of cytotoxic function and the percentage of cells with NK phenotype (GM-1+). Thus, LENK modulates cytolytic functions and the phenotype of NK cells in vivo in a complex way, which besides opioid mechanisms may also include non-opioid ones.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Mariastefania Antica (autor)

Avatar Url Jelka Gabrilovac (autor)

Avatar Url Maja Osmak (autor)

Citiraj ovu publikaciju

Gabrilovac, Jelka; Antica, Mariastefania; Osmak, Maja
In vivo bidirectional regulation of mouse natural killer (NK) cell cytotoxic activities by Leu-enkephalin: Reversibility by naloxone // Life sciences, 50 (1992), 1; 29-37 doi:10.1016/0024-3205(92)90194-T (međunarodna recenzija, članak, znanstveni)
Gabrilovac, J., Antica, M. & Osmak, M. (1992) In vivo bidirectional regulation of mouse natural killer (NK) cell cytotoxic activities by Leu-enkephalin: Reversibility by naloxone. Life sciences, 50 (1), 29-37 doi:10.1016/0024-3205(92)90194-T.
@article{article, year = {1992}, pages = {29-37}, DOI = {10.1016/0024-3205(92)90194-T}, keywords = {Leu-enkephalin, bidirectional immunomodulation, NK-cells, ADCC, opioid receptors}, journal = {Life sciences}, doi = {10.1016/0024-3205(92)90194-T}, volume = {50}, number = {1}, issn = {0024-3205}, title = {In vivo biderectional regulation of mouse natural killer (NK) cell cytotoxic activities by Leu-Enkephalin: Reversibility by naloxone}, keyword = {Leu-enkephalin, bidirectional immunomodulation, NK-cells, ADCC, opioid receptors} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati