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Pregled bibliografske jedinice broj: 243569

Bioactive 1, 4-dihydroisonicotinic acid derivatives prevent oxidative damage of liver cells


Borović, Suzana; Tirzitis, Gunars; Tirzite, Dace; Čipak, Ana; Khoschsorur, Gholam A.; Waeg, Georg; Tatzber, Franz; Šćukanec-Špoljar, Mira; Žarković, Neven
Bioactive 1, 4-dihydroisonicotinic acid derivatives prevent oxidative damage of liver cells // European Journal of Pharmacology, 535 (2006), 1-3; 12-19 (međunarodna recenzija, članak, znanstveni)


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Naslov
Bioactive 1, 4-dihydroisonicotinic acid derivatives prevent oxidative damage of liver cells

Autori
Borović, Suzana ; Tirzitis, Gunars ; Tirzite, Dace ; Čipak, Ana ; Khoschsorur, Gholam A. ; Waeg, Georg ; Tatzber, Franz ; Šćukanec-Špoljar, Mira ; Žarković, Neven

Izvornik
European Journal of Pharmacology (0014-2999) 535 (2006), 1-3; 12-19

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
1; 4-Dihydropyridine; Antioxidants; Lipid peroxidation; Malondialdehyde; 4-Hydroxynonenal; Hepatoprotection

Sažetak
1, 4-Dihydroisonicotinic acid derivatives (1, 4-DHINA) are compounds closely related to derivatives of 1, 4-dihydropyridine, a well-known calcium channel antagonists. 1, 4-DHINA we used were derived from a well-known antioxidant Diludin. Although some compounds have neuromodulatory or antimutagenic properties, the activity mechanisms are not well known. This study was performed to obtain data on antioxidant and bioprotective activities of: 2, 6-dimethyl-3, 5-diethoxycarbonyl-1, 4-dihydroisonicotinic acid (Ia) ; sodium 2-(2, 6-dimethyl-3, 5-diethoxycarbonyl-1, 4-dihydropyridine-4-carboxamido)glutamate (Ib) and sodium 2-(2, 6-dimethyl-3, 5-diethoxycarbonyl-1, 4-dihydropyridine-4-carboxamido)ethane-sulphate (Ic). 1, 4-DHINA’ s activities were studied in comparison to Trolox by: DPPH., deoxyribose degradation, ABTS radical scavenging and ANTIOX-CAP assays ; copper-induced lipid peroxidation of cultured rat liver cells (malondialdehyde determination by HPLC and 4-hydroxynonenal by dot-blot) ; 3H-thymidine incorporation and trypan-blue assay for liver cells growth and viability. In all assays used Ia was the most potent antioxidant. Ia was also potent antioxidant at non-toxic concentrations for liver cell cultures. It completely abolished, while Ic only slightly decreased copper-induced lipid peroxidation of liver cells. Thus, antioxidant capacities are important activity principle of Ia, which was even superior to Trolox in the cell cultures used, while activity principles of Ic and Ib remain yet to be determined.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
0198016
0098101
0108254

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Borović, Suzana; Tirzitis, Gunars; Tirzite, Dace; Čipak, Ana; Khoschsorur, Gholam A.; Waeg, Georg; Tatzber, Franz; Šćukanec-Špoljar, Mira; Žarković, Neven
Bioactive 1, 4-dihydroisonicotinic acid derivatives prevent oxidative damage of liver cells // European Journal of Pharmacology, 535 (2006), 1-3; 12-19 (međunarodna recenzija, članak, znanstveni)
Borović, S., Tirzitis, G., Tirzite, D., Čipak, A., Khoschsorur, G., Waeg, G., Tatzber, F., Šćukanec-Špoljar, M. & Žarković, N. (2006) Bioactive 1, 4-dihydroisonicotinic acid derivatives prevent oxidative damage of liver cells. European Journal of Pharmacology, 535 (1-3), 12-19.
@article{article, year = {2006}, pages = {12-19}, keywords = {1, 4-Dihydropyridine, Antioxidants, Lipid peroxidation, Malondialdehyde, 4-Hydroxynonenal, Hepatoprotection}, journal = {European Journal of Pharmacology}, volume = {535}, number = {1-3}, issn = {0014-2999}, title = {Bioactive 1, 4-dihydroisonicotinic acid derivatives prevent oxidative damage of liver cells}, keyword = {1, 4-Dihydropyridine, Antioxidants, Lipid peroxidation, Malondialdehyde, 4-Hydroxynonenal, Hepatoprotection} }
@article{article, year = {2006}, pages = {12-19}, keywords = {1, 4-Dihydropyridine, Antioxidants, Lipid peroxidation, Malondialdehyde, 4-Hydroxynonenal, Hepatoprotection}, journal = {European Journal of Pharmacology}, volume = {535}, number = {1-3}, issn = {0014-2999}, title = {Bioactive 1, 4-dihydroisonicotinic acid derivatives prevent oxidative damage of liver cells}, keyword = {1, 4-Dihydropyridine, Antioxidants, Lipid peroxidation, Malondialdehyde, 4-Hydroxynonenal, Hepatoprotection} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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