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Pregled bibliografske jedinice broj: 243557

Defects of natural killer cell activity in children with untreated acute lymphocytic leukemia


Gabrilovac, Jelka; Boranić, Milivoj; Batinić, Drago; Kušić, Borka; et al.,
Defects of natural killer cell activity in children with untreated acute lymphocytic leukemia // Wiener Klinische Wochenschrift, 66 (1988), 8; 354-360 (međunarodna recenzija, članak, znanstveni)


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Naslov
Defects of natural killer cell activity in children with untreated acute lymphocytic leukemia

Autori
Gabrilovac, Jelka ; Boranić, Milivoj ; Batinić, Drago ; Kušić, Borka ; et al.,

Izvornik
Wiener Klinische Wochenschrift (0043-5325) 66 (1988), 8; 354-360

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
natural-killer cells; untreated acute lymphatic leukemia; interferon-gamma

Sažetak
Natural killer (NK) activity against cells of the K-562 line was significantly depressed in 12 of 18 children (66%) with untreated acute lymphocytic leukemia (ALL). No suppression of allogeneic NK activity was observed with sera of the patients, regardless of the level of NK depression. The ability of peripheral blood lymphocytes (PBLs) to suppress allogeneic NK activity was tested in two ALL patients - one with no detectable NK activity, and one with high NK activity. No NK-suppressive activity was found with PBLs of the areactive patient ; PBLs of the reactive patients exhibited some suppressive activity, but only at a particular suppressor-to-effector cell ratio. Leukemic blasts were resistant to killing by autologous NK cells stimulated by IFN, as well as to killing by allogeneic, IFN-stimulated PBLs. Leukemic blasts of an ALL patient inhibited lysis of K-562 cells in an 18-h, but not in a 4-h NK assay. The inhibition could partly be reversed by pretreatment of ALL cells with alpha interferon, suggesting that the blasts might inhibit the lysis of K-562 targets in a competitive manner. Disturbed function and/or regulation of NK cells may influence attempts at NK cell activation by lymphokines.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Milivoj Boranić (autor)

Avatar Url Jelka Gabrilovac (autor)

Avatar Url Drago Batinić (autor)

Avatar Url Borka Kušić (autor)


Citiraj ovu publikaciju:

Gabrilovac, Jelka; Boranić, Milivoj; Batinić, Drago; Kušić, Borka; et al.,
Defects of natural killer cell activity in children with untreated acute lymphocytic leukemia // Wiener Klinische Wochenschrift, 66 (1988), 8; 354-360 (međunarodna recenzija, članak, znanstveni)
Gabrilovac, J., Boranić, M., Batinić, D., Kušić, B. & et al., . (1988) Defects of natural killer cell activity in children with untreated acute lymphocytic leukemia. Wiener Klinische Wochenschrift, 66 (8), 354-360.
@article{article, year = {1988}, pages = {354-360}, keywords = {natural-killer cells, untreated acute lymphatic leukemia, interferon-gamma}, journal = {Wiener Klinische Wochenschrift}, volume = {66}, number = {8}, issn = {0043-5325}, title = {Defects of natural killer cell activity in children with untreated acute lymphocytic leukemia}, keyword = {natural-killer cells, untreated acute lymphatic leukemia, interferon-gamma} }
@article{article, year = {1988}, pages = {354-360}, keywords = {natural-killer cells, untreated acute lymphatic leukemia, interferon-gamma}, journal = {Wiener Klinische Wochenschrift}, volume = {66}, number = {8}, issn = {0043-5325}, title = {Defects of natural killer cell activity in children with untreated acute lymphocytic leukemia}, keyword = {natural-killer cells, untreated acute lymphatic leukemia, interferon-gamma} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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