engleski

Oral maintenance ritodrine tocolysis after active preterm labor: randomized controlled trial

Objective: To assess the efficacy of ritodtine in the form of sustained release capsules for maintenance uterine quiescence after successful treatment of pre term labor (PTL). Design: Randomized controlled trial. Setting: Tertiary referral centre. Population: 120 women in singleton pregnancy with threatened PTL before completed 34 weeks being successfully treated with intravenous ritodrine and not progressing to delivery without clinical and laboratory signs of infection. Methods: Those women were randomized either to receive two 40 mg ritodrine sustained release capsules three times a day (study group, n=62) or no treatment with bed rest (control group, n=58) for three days. The primary outcome measure was the recurrent episode of threatened PTL within next 48-72 hours. Secondary outcome measures were taken out from the pregnancy outcome and the incidence of side effects of maintenance ritodrine therapy. Results: There was no difference in the need for another course of treatment because of recurrent episode of threatened PTL comparing the group of women taking oral maintenance ritodrine therapy compared to women with bed rest only (8 of 62 vs. 6 of 58, p=0.45). As well as that there was no differences found in the predefined secondary outcome measures (delivery before 37 weeks, 13 vs. 7, p=0.15 ; delivery before 34 weeks, 3 vs. 1, p=0.6 ; birth weight, 3035g vs. 3223g, p=0.86), except in the incidence of mild side effect being the more frequent in the group taking oral ritodrine (48 vs. 23, p=0.003). Conclusions: We believe that there is no need for additional maintenance ritodrine therapy in singleton pregnancy for women who have an episode of threatened PTL and are successfully treated with intravenous tocolytic therapy.

preterm labor; maintenance tocolysis; oral tocolysis

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