engleski

Effects of chronic organic solvent exposure on event related potentials in man - A P-300 study

The organic solvent xylene is known to be a human neurotoxicant. At the Department of Pathology a group of medical workers (4 male, 31 female, mean age 36 +/-7.7 yrs.), exposed to elevated daily inhalation of xylene (1000-3000 mg/m3 in the working environment) for at least five years, was tested using an auditory "oddball" paradigm (25% target stimuli). All subjects underwent psycohological testing.The latency of P-300 was significantly prolonged in the group of medical workers, when compared to a non-exposed, age-matched control group (n=21) (378+/-12 ms, p<0.001, ANOVA). The amplitude of P-300 was significantly reduced when compared to the control group (10.0 +/-4 uV vs. 12.6 +/-4 uV, p<0.05, ANOVA). Psychological testing in the group of medical workers revealed results within the expected range and significant correlation (r=0.41) between P-300 latency and psychological parameter for the CDR 1.1 test (convergent thinking). The obtained neuropsychological data showed sighificant difference between the group of medical workers and the control group. The results of this study represent a basis for further research.

P-300; chronic organic solvent exposure; xylene

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