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Pregled bibliografske jedinice broj: 240379

Met-enkephalin induced escape from dexamethasone immunosuppression


Haberstock Debić, Helena; Marotti, Tatjana
Met-enkephalin induced escape from dexamethasone immunosuppression // Neuropeptides, 25 (1993), 3; 199-206 doi:10.1016/0143-4179(93)90103-H (međunarodna recenzija, članak, znanstveni)


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Naslov
Met-enkephalin induced escape from dexamethasone immunosuppression

Autori
Haberstock Debić, Helena ; Marotti, Tatjana

Izvornik
Neuropeptides (0143-4179) 25 (1993), 3; 199-206

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Met-enkephalin ; dexamethasone

Sažetak
The present study was undertaken to examine whether and what type of interaction occurs between a synthetic glucocorticoid, dexamethasone (DEX) and an opioid peptide, met-enkephalin (MENK) upon superoxide anion (O2−) release from human polymorphonuclear cells (PMN). MENK (10−8 M) abolished suppressed O2− release from PMNs treated with 10−7 M DEX. This was the case in unstimulated but not in PMNs stimulated with PMA. The effect of MENK was mediated through pertussis-toxin (PTX) sensitive G-protein and since it was abolished by H7 probably involves protein kinase C (PKC) as a second messenger system. Thus, MENK can abolish DEX induced suppression of O2− release from human PMNs possibly through the interaction of second messenger pathways.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Haberstock Debić, Helena; Marotti, Tatjana
Met-enkephalin induced escape from dexamethasone immunosuppression // Neuropeptides, 25 (1993), 3; 199-206 doi:10.1016/0143-4179(93)90103-H (međunarodna recenzija, članak, znanstveni)
Haberstock Debić, H. & Marotti, T. (1993) Met-enkephalin induced escape from dexamethasone immunosuppression. Neuropeptides, 25 (3), 199-206 doi:10.1016/0143-4179(93)90103-H.
@article{article, year = {1993}, pages = {199-206}, DOI = {10.1016/0143-4179(93)90103-H}, keywords = {Met-enkephalin, dexamethasone}, journal = {Neuropeptides}, doi = {10.1016/0143-4179(93)90103-H}, volume = {25}, number = {3}, issn = {0143-4179}, title = {Met-enkephalin induced escape from dexamethasone immunosuppression}, keyword = {Met-enkephalin, dexamethasone} }
@article{article, year = {1993}, pages = {199-206}, DOI = {10.1016/0143-4179(93)90103-H}, keywords = {Met-enkephalin, dexamethasone}, journal = {Neuropeptides}, doi = {10.1016/0143-4179(93)90103-H}, volume = {25}, number = {3}, issn = {0143-4179}, title = {Met-enkephalin induced escape from dexamethasone immunosuppression}, keyword = {Met-enkephalin, dexamethasone} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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