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Pregled bibliografske jedinice broj: 240361

Interaction of Met-enkephalin and corticosteroids in immunomodulation


Marotti, Tatjana; Ročić, Boris; Gabrilovac, Jelka; Haberstock Debić, Helena
Interaction of Met-enkephalin and corticosteroids in immunomodulation // International Journal of Immunopharmacology, 14 (1992), 4; 621-627 doi:10.1016/0192-0561(92)90123-3 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 240361 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Interaction of Met-enkephalin and corticosteroids in immunomodulation

Autori
Marotti, Tatjana ; Ročić, Boris ; Gabrilovac, Jelka ; Haberstock Debić, Helena

Izvornik
International Journal of Immunopharmacology (0192-0561) 14 (1992), 4; 621-627

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Met-enkephalin ; corticosteroid

Sažetak
The effect of Met-enkephalin (MENK) on several immune functions, corticosterone (CS) and adrenocorticotropin (ACTH) levels in the plasma was studied in adrenalectomized (ADX) and sham-adrenalectomized (SADX) mice. Multiple Met-enkephalin injections (10 mg/kg per day in two injections 12 h apart, for 4 days) increased the plaque-forming cell response to sheep erythrocytes in the spleen and enhanced the proliferation of spleen cells in vitro. These effects were comparable in sham-adrenalectomized and adrenalectomized mice. However, spleen cells of mice immunized with sheep red blood cells and injected with Met-enkephalin, showed suppressed blastogeneic transformation with Con A. The effect was equal in adrenalectomized and sham-adrenalectomized mice. In the absence of Con A in spleen cell cultures, MENK treatment of donor mice resulted in a significant mitogenic effect. NK activity of the spleen cells was suppressed in MENK-treated adrenalectomized mice. Injection of MENK decreased corticosterone levels and increased ACTH levels in the plasma of sham-adrenalectomized mice. In adrenalectomized mice plasma levels of ACTH were decreased by MENK. It seems that corticosteroid secretion, although changed by adrenalectomy and influenced by treatment with MENK, does not influence the modulatory effect of MENK on the PFC response and blastogeneic transformation of mouse spleen cells. However, NK activity of the spleen cells treated with MENK seems to the reflect joint action of MENK and corticosteroids.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac,
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Marotti, Tatjana; Ročić, Boris; Gabrilovac, Jelka; Haberstock Debić, Helena
Interaction of Met-enkephalin and corticosteroids in immunomodulation // International Journal of Immunopharmacology, 14 (1992), 4; 621-627 doi:10.1016/0192-0561(92)90123-3 (međunarodna recenzija, članak, znanstveni)
Marotti, T., Ročić, B., Gabrilovac, J. & Haberstock Debić, H. (1992) Interaction of Met-enkephalin and corticosteroids in immunomodulation. International Journal of Immunopharmacology, 14 (4), 621-627 doi:10.1016/0192-0561(92)90123-3.
@article{article, year = {1992}, pages = {621-627}, DOI = {10.1016/0192-0561(92)90123-3}, keywords = {Met-enkephalin, corticosteroid}, journal = {International Journal of Immunopharmacology}, doi = {10.1016/0192-0561(92)90123-3}, volume = {14}, number = {4}, issn = {0192-0561}, title = {Interaction of Met-enkephalin and corticosteroids in immunomodulation}, keyword = {Met-enkephalin, corticosteroid} }
@article{article, year = {1992}, pages = {621-627}, DOI = {10.1016/0192-0561(92)90123-3}, keywords = {Met-enkephalin, corticosteroid}, journal = {International Journal of Immunopharmacology}, doi = {10.1016/0192-0561(92)90123-3}, volume = {14}, number = {4}, issn = {0192-0561}, title = {Interaction of Met-enkephalin and corticosteroids in immunomodulation}, keyword = {Met-enkephalin, corticosteroid} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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