engleski

Effects of clenbuterol on insulin and glucose sensitivity in pigs after subacute treatment with growth-promoting dose.

The effects on glucose, non-esterified fatty acids and insulin are mediated by BAA , such as clenbuterol . The intensity of these effects depends on the BAA type, animal species, and especially on the duration of BAA treatment, i.e. acute or long-term exposure. Acute effects of therapeutic and growth-promoting doses entail significant changes in the levels of insulin and glucose in the blood of calves after the treatment with clenbuterol. However, different results have been reported after long-term treatment with clenbuterol, e.g., a slightly decreased insulin level and glucose level similar to that found in control pigs. In the present study, subacute treatment with clenbuterol decreased the serum insulin level in pigs after the treatment, however, all insulin levels remained within the physiologic range.Thus, the treated pigs exhibited no glucose response to insulin values. In conclusion, the results obtained suggested the effects of subacute treatment of pigs with a growth-promoting dose of clenbuterol on the observed biochemical parameters to be comparable to those elicited by long-term clenbuterol treatment, whereby the importance of other metabolic effects of long-term treatment on nutrient repartition outweighs the acute effects reported.

growth-promoting agents; clenbuterol; insulin; glucose; pigs

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