engleski

Mechanism of the immunosuppressive effect of Ehrlich ascitic tumour

Mice were given one i.p. injection of 0·3 ml of the cell-free Ehrlich ascitic fluid (EAF). Seven to 14 days later, the generation of antibody-forming cells (PFC's) in their spleens was suppressed. However, when spleen cells from EAF treated mice were transfered into normal lethally irradiated recipients, the cells were able to generate normal numbers of PFC's. On the other hand, spleen cells or bone marrow and thymus cell mixtures from normal donors were also completely inefficient in producing PFC's when assayed in EAF-treated and irradiated recipients. Incubation of spleen cells, bone marrow cells or thymus cells with EAF prior to transplantation, as well as simultaneous injection of spleen cells together with EAF into irradiated animals, did not inhibit the normal immune performances of these cells. These data suggest that EAF may induce immunosuppression by changing the microenvironment in the spleen, rather than by acting directly on the cells involved in the immune response.

immunosuppressive effect ; Ehrlich ascitic tumour.

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