engleski

"Cooperation" of normal and malignant lymphoid cells in the immune response against sheep erythrocytes

Cells of a lymphoid leukemia were injected into lethally irradiated syngeneic mice, together with antigen (sheep erythrocytes) and normal thymocytes or bone marrow cells, to see whether they could participate in cellular interactions leading to the formation of antibody forming cells (PFC). Few PFC were generated by leukemia cells given alone or mixed with bone marrow, but many PFC grew from the mixture of leukemia cells and thymocytes. Thus, leukemia cells resembled normal B lymphocytes. They might have become PFC through cooperation with thymus cells, or simply by having attached (by means of surface receptors) antibodies formed by normal B lymphocytes present in the inoculum.

malignant ; lymphoid ; cells ; immune response

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