engleski

Immunosuppression mediated by Ehrlich ascites fluid.

One intraperitoneal injection of cell-free Ehrlich ascites fluid, which did not induce the tumour, inhibited very strongly, and for a long time, the formation of antibody-producing cells (PFC's) in the spleens of recipient mice. The same procedure did not alter cellular immunological reactivity of these splenocytes (assayed by graft-vs-host reaction). At the time when the strongest suppression of PFC formation was registered, cellularity of the spleens increased. Several interpretations of these data are given, the most attractive one being that immunosuppressive agent(s) present in the ascitic fluid of Ehrlich tumour selectively eliminated or inhibited function of the population of B lymphocytes.

Immunosuppression ; Ehrlich ascites fluid

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