engleski

Decrease in CD23+B lymphocytes and clinical outcome in asthmatic patients receiving specific rush immunotherapy

Rush immunotherapy (RIT) has been documented as useful in the treatment of patients with allergic bronchial asthma.To investigate the mechanisms of its action, we studied changes in the serum level of total IgE, allergen-specific IgE and IgG4, and expression of CD23 on peripheral blood B cells in patients receiving RIT. Twenty patients with perennial bronchial asthma were evaluatedbefore the beginning of RIT, as well as 6 weeks and 6 months later.Compared to pretreatment values, the level of Der p-specific IgG4 and IgE significantly increased after six weeks, and 6 months of RIT, the percentage of CD23+B cells and its CD23 receptor density significantly decreased. These findings suggest a change in the lymphokine profiles of patients receiving RIT, and that the inhibiotion of IL-4- induced B-cell stimulation may be hypothesized as the most important mechanism.

CD23+ B cells ; IgE ; IgG4 ; Der p ; rush immunotherapy

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