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Kinetic model of tocopherol-mediated peroxidation (CROSBI ID 468984)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija

Herak, Janko ; Krilov, Dubravka ; Stojanović, Nataša Kinetic model of tocopherol-mediated peroxidation // Book of abstracts, Annual Meeting of Croatian Biochemists / Glavaš-Obrovac, Ljubica (ur.). Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 1998. str. 87-87-x

Podaci o odgovornosti

Herak, Janko ; Krilov, Dubravka ; Stojanović, Nataša

engleski

Kinetic model of tocopherol-mediated peroxidation

Slow oxidation of low-density lipoprotein (LDL) is characterized by tocopherol-mediated peroxidation. Our experiments, performed under the conditions of very mild oxidation in a closed system (with the presence of EDTA), gave the evidence that in this process alpha-tocopherol (TH) was not used to a detectable level in several days. At the same time, after about one day, oxygen was consumed and peroxides were fromed. The further phase of the process was characterized by the reduction of peroxides and the generation of free radicals, trapped predominantly on the apoprotein. Bases on these experimental observations, a kinetic model of tocopherol-mediated oxidation of LDL has been developed. The initiation phase of oxidation was modelled by processes that are associated with the switching of the chelated metal ions between the oxidized and reduced states, and simultaneous switching of TH between the reduced and oxidized states. These processes include homolytic cleavage of preexisting lipid hydroperoxides (LOOH), and subsequent formation of lipid hydroxides (LOH) and destruction of co-antioxidants. In the second phase The lipid (L.) and lipid peroxy radicals (LOO.) serve as chain propagating species, together with the oscillation of tocopherol between TH and T. states. In the final phase, after consumption of oxygen, lipid peroxides decompose and free radicals are formed, which react with the protein moiety and ultimately terminate the process.

LDL oxidation; Heterogeneous kinetics; Compartments; Probabilistic kinetic model

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Podaci o prilogu

87-87-x.

1998.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Book of abstracts, Annual Meeting of Croatian Biochemists

Glavaš-Obrovac, Ljubica

Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu

Podaci o skupu

Godišnji sastanak hrvatskih biokemičara

poster

17.09.1998-20.09.1998

Hrvatska

Povezanost rada

Temeljne medicinske znanosti