Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 23799

Kinetic model of tocopherol-mediated peroxidation


Herak, Janko; Krilov, Dubravka; Stojanović, Nataša
Kinetic model of tocopherol-mediated peroxidation // Book of abstracts, Annual Meeting of Croatian Biochemists / Glavaš-Obrovac, Ljubica (ur.).
Zagreb: Farmaceutsko-biokemijski fakultet, 1998. str. 87-87 (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 23799 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Kinetic model of tocopherol-mediated peroxidation

Autori
Herak, Janko ; Krilov, Dubravka ; Stojanović, Nataša

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts, Annual Meeting of Croatian Biochemists / Glavaš-Obrovac, Ljubica - Zagreb : Farmaceutsko-biokemijski fakultet, 1998, 87-87

Skup
Godišnji sastanak hrvatskih biokemičara

Mjesto i datum
Bizovačke toplice, Hrvatska, 17-20. rujna 1998

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
LDL oxidation; Heterogeneous kinetics; Compartments; Probabilistic kinetic model

Sažetak
Slow oxidation of low-density lipoprotein (LDL) is characterized by tocopherol-mediated peroxidation. Our experiments, performed under the conditions of very mild oxidation in a closed system (with the presence of EDTA), gave the evidence that in this process alpha-tocopherol (TH) was not used to a detectable level in several days. At the same time, after about one day, oxygen was consumed and peroxides were fromed. The further phase of the process was characterized by the reduction of peroxides and the generation of free radicals, trapped predominantly on the apoprotein. Bases on these experimental observations, a kinetic model of tocopherol-mediated oxidation of LDL has been developed. The initiation phase of oxidation was modelled by processes that are associated with the switching of the chelated metal ions between the oxidized and reduced states, and simultaneous switching of TH between the reduced and oxidized states. These processes include homolytic cleavage of preexisting lipid hydroperoxides (LOOH), and subsequent formation of lipid hydroxides (LOH) and destruction of co-antioxidants. In the second phase The lipid (L.) and lipid peroxy radicals (LOO.) serve as chain propagating species, together with the oscillation of tocopherol between TH and T. states. In the final phase, after consumption of oxygen, lipid peroxides decompose and free radicals are formed, which react with the protein moiety and ultimately terminate the process.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
006110

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Nataša Stojanović (autor)

Avatar Url Janko Herak (autor)

Avatar Url Dubravka Krilov (autor)


Citiraj ovu publikaciju:

Herak, Janko; Krilov, Dubravka; Stojanović, Nataša
Kinetic model of tocopherol-mediated peroxidation // Book of abstracts, Annual Meeting of Croatian Biochemists / Glavaš-Obrovac, Ljubica (ur.).
Zagreb: Farmaceutsko-biokemijski fakultet, 1998. str. 87-87 (poster, domaća recenzija, sažetak, znanstveni)
Herak, J., Krilov, D. & Stojanović, N. (1998) Kinetic model of tocopherol-mediated peroxidation. U: Glavaš-Obrovac, L. (ur.)Book of abstracts, Annual Meeting of Croatian Biochemists.
@article{article, editor = {Glava\v{s}-Obrovac, L.}, year = {1998}, pages = {87-87}, keywords = {LDL oxidation, Heterogeneous kinetics, Compartments, Probabilistic kinetic model}, title = {Kinetic model of tocopherol-mediated peroxidation}, keyword = {LDL oxidation, Heterogeneous kinetics, Compartments, Probabilistic kinetic model}, publisher = {Farmaceutsko-biokemijski fakultet}, publisherplace = {Bizova\v{c}ke toplice, Hrvatska} }
@article{article, editor = {Glava\v{s}-Obrovac, L.}, year = {1998}, pages = {87-87}, keywords = {LDL oxidation, Heterogeneous kinetics, Compartments, Probabilistic kinetic model}, title = {Kinetic model of tocopherol-mediated peroxidation}, keyword = {LDL oxidation, Heterogeneous kinetics, Compartments, Probabilistic kinetic model}, publisher = {Farmaceutsko-biokemijski fakultet}, publisherplace = {Bizova\v{c}ke toplice, Hrvatska} }




Contrast
Increase Font
Decrease Font
Dyslexic Font