Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 237909

Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms


Pivac, Nela; Kozarić-Kovačić, Dragica; Mustapić, Maja; Deželjin, Martina; Borovečki, Andreja; Grubišic-Ilić, Mirjana; Muck-Šeler, Dorotea
Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms // Journal of Affective Disorders, 93 (2006), 1-3; 223-227 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 237909 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms

Autori
Pivac, Nela ; Kozarić-Kovačić, Dragica ; Mustapić, Maja ; Deželjin, Martina ; Borovečki, Andreja ; Grubišic-Ilić, Mirjana ; Muck-Šeler, Dorotea

Izvornik
Journal of Affective Disorders (0165-0327) 93 (2006), 1-3; 223-227

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
combat related posttraumatic stress disorder; psychotic symptoms; platelet serotonin; war veterans

Sažetak
Background: Combat-related posttraumatic stress disorder (PTSD) is severe form of PTSD, frequently associated with psychotic symptoms. Platelet serotonin (5-hydroxytryptamine, 5-HT) was used as a peripheral 5-HT marker to identify particular symptoms in PTSD. Methods: Platelet 5-HT was determined fluorimetrically in 67 war veterans with combat related PTSD, 36 combat exposed veterans who did not develop PTSD, 35 veterans with PTSD complicated with psychotic features. PTSD diagnosis of current and chronic PTSD, and clinical symptoms of PTSD and psychoses were assessed according to DSM-IV criteria, using the Clinician Administrated PTSD Scale, and Positive and Negative Syndrome Scale (PANSS). Results: Platelet 5-HT concentration was significantly higher in veterans with psychotic PTSD than in veterans with non-psychotic PTSD, veterans without PTSD, or in control subjects. Platelet 5-HT was significantly positively correlated with the positive symptoms in PANSS subscale, and with the symptoms of delusions within PANSS positive subscale. Limitations: The results were obtained on peripheral 5-HT marker, i.e. platelet 5-HT concentration. Conclusions: Since the delusions are the core psychotic symptoms occurring in our psychotic PTSD patients, the result of the increased platelet 5-HT concentration, associated with delusions, indicate that platelet 5-HT might be used as a trait marker of psychotic symptoms in PTSD, but not as a state marker for PTSD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
0098088

Ustanove
Institut "Ruđer Bošković", Zagreb,
Klinička bolnica "Dubrava"

Citiraj ovu publikaciju

Pivac, Nela; Kozarić-Kovačić, Dragica; Mustapić, Maja; Deželjin, Martina; Borovečki, Andreja; Grubišic-Ilić, Mirjana; Muck-Šeler, Dorotea
Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms // Journal of Affective Disorders, 93 (2006), 1-3; 223-227 (međunarodna recenzija, članak, znanstveni)
Pivac, N., Kozarić-Kovačić, D., Mustapić, M., Deželjin, M., Borovečki, A., Grubišic-Ilić, M. & Muck-Šeler, D. (2006) Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms. Journal of Affective Disorders, 93 (1-3), 223-227.
@article{article, year = {2006}, pages = {223-227}, keywords = {combat related posttraumatic stress disorder, psychotic symptoms, platelet serotonin, war veterans}, journal = {Journal of Affective Disorders}, volume = {93}, number = {1-3}, issn = {0165-0327}, title = {Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms}, keyword = {combat related posttraumatic stress disorder, psychotic symptoms, platelet serotonin, war veterans} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE