C-reactive Protein is a Strong Predictor of Mortality in Haemodialysis Patients (CROSBI ID 121174)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Rački, Sanjin ; Zaputović, Luka ; Vujičić, Božidar ; Dvornik, Štefica ; Mavrić, Žarko
engleski
C-reactive Protein is a Strong Predictor of Mortality in Haemodialysis Patients
Background: To establish the baseline cut-off value of C-reactive protein (CRP) that may be predictive of increased overall and cardiovascular mortality in patients with end-stage renal disease (ESRD). Methods: A cohort of 270 prevalent haemodialysis patients treated at Rijeka University Hospital were eligible for the study. Monthly CRP measurements were performed for three consecutive months. Only the patients with CRP values varying <20% were included (n=256). During the follow up, 24 patients were transplanted and therefore excluded from the analysis. The CRP cut-off point of 6.2 mg/L was established by Receiver Operating Characteristic curve. The patients were divided into four groups according to their CRP values. Group 1 included 80 (34.5%) patients with CRP <3.0 mg/L, group 2 included 23 (9.9%) patients with CRP 3.0-6.1 mg/L, group 3 consisted of 18 (7.7%) patients with CRP 6.2-10.0 mg/L, and group 4 included 111 (47.9%) patients with CRP >10.0 mg/L. The survival was evaluated by Kaplan-Meier curve. Results: During the 2-year follow-up, 59 patients died. The major cause of death was cardiovascular disease (64%). Significantly higher overall and cardiovascular mortality was observed in group 3 when compared with groups 1 and 2 (chi square=11.97 ; P < 0.001), and in group 4 when compared with groups 1 and 2 (chi square=14.40 ; P<0.001). Compared with survivors, non-survivors had a higher median CRP value (19.0 [1.5-99.7] mg/L vs. 2.3 [0.1-49.1] mg/L, respectively ; P<0.001). Conclusion: Serum concentration of CRP above 6.2 mg/L is a strong predictor of overall and cardiovascular mortality in patients with ESRD.
C-reactive protein; Renal dialysis; Kidney failure; chronic: Mortality; Inflammation
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