TFF2 (trefoil family factor2) inhibits apoptosis in breast and colorectal cancer cell lines (CROSBI ID 120472)
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Podaci o odgovornosti
Siu, Lai-San ; Romanska, Hanna ; Abel, D Paul ; Baus-Lončar, Mirela ; Kayademir, Tuncay ; Stamp, W.H. Gordon ; Lalani, El-Nasir Lalani
engleski
TFF2 (trefoil family factor2) inhibits apoptosis in breast and colorectal cancer cell lines
We have recently demonstrated that human TFF2 inhibits apoptosis in the non-TFF2 expressing breast adenocarcinoma cell line MCF-7. In this study we examined the impact of TFF2 and an anti-TFF2 antibody (hSP3) on the survival of other human adenocarcinoma cell lines ; TFF2-positive (LS174T and SW480) and TFF2-negative (MCF-7 and T47D). Addition of TFF2 protected the (TFF2– ) lines but had no effect on those constitutively expressing TFF2. Blocking with hSP3 significantly increased apoptosis in the (TFF2+) cell lines with minimal effect on the (TFF2– ) cells. Our results show that the cytoprotective effect of TFF2 seen in MCF-7 cells is not cell line-specific and can be abrogated by inhibition of its expression.
TFF2 ; Adenocarcinoma ; Cytoprotection
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Podaci o izdanju
Povezanost rada
Biologija, Temeljne medicinske znanosti