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Changes in vitamin E concentration after surgery and anesthesia (CROSBI ID 120004)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Žunić, J. ; Stavljenić Rukavina, Ana ; Granić, Paula ; Žanić-Matanić, D. ; Husedžinović, I. ; Romić, Z. ; Holosek, A. ; Belavić, Z. Changes in vitamin E concentration after surgery and anesthesia // Collegium antropologicum, 21 (1997), 1; 327-334

Podaci o odgovornosti

Žunić, J. ; Stavljenić Rukavina, Ana ; Granić, Paula ; Žanić-Matanić, D. ; Husedžinović, I. ; Romić, Z. ; Holosek, A. ; Belavić, Z.

engleski

Changes in vitamin E concentration after surgery and anesthesia

The aim of this randomized study was to examine changes in vitamin E concentration in female subjects (age 30-60, ASA I) after cholecystectomy and halothane (N = 16) or isoflurane (N = 16) anaesthesia. Vitamin E concentration was measured two days before, and then one, five and twenty-four hours and four days after surgery. High-pressure liquid chromatography was used for its determination. Simultaneously activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyltransferase (GGT) were determined. Statistical analysis: ANOVA, Tukay HSD test. The research has been accepted by the Drugs Committee of the Karlovac County Hospital. Preoperative vitamin E concentrations in the halothane group were 8.69 +/- 2.35 micrograms/L, median 8.67 micrograms/L and in the isoflurane group 9.43 +/- 2.4 micrograms/L, median 9.08 micrograms/L. Statistically lower vitamin E concentrations compared with preoperative values were noted one hour (P < 0.05), 5 hours (P < 0.01), 24 hours (P < 0.01), as well as 4 days (P < 0.01) after the operation. The lowest vitamin E concentrations were noted 24 hours after the operation with statistically insignificantly higher values in the isoflurane group (halothane group 5.98 +/- 2.08 micrograms/L, isoflurane group 6.58 +/- 1.51 micrograms/L). Analyzing enzyme (ALT, AST and GGT) pre- and postoperative values, no statistically significant differences between the investigated groups and during the time were observed. Statistically significant differences were found between individual measurement times, with no statistical significance of the differences between the halothane and isoflurane groups. It seems that neither the difference in halothane and isoflurane biotransformation nor their distinct effect on perfusion of some organs are the determining factors in post-operative changes in vitamin E concentration

vitamin E

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

21 (1)

1997.

327-334

objavljeno

0350-6134

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost