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The influence of methylprednisolon and gastric pentadecapeptide on cutaneous flap survival

Idea: There are plenty of recent studies showing the influence of different drugs on the survival of the cutaneous flap. The effects of a topically applied methylprednisolon and gastric pentadecapeptide in improving skin vitality and preventing distal flap necrosis were tested in a random-pattern dorsal skin flap model. Method: Wistar rats were randomized into 3 groups, 2 experimental groups and a control group. A standardized full thickness dorsal random-pattern skin flap was raised on each rat and sutured back into place. In the experimental groups methylprednisolon and gastric pentadecapeptide BPC-157 were topically applied. The flap survival was judged one week postoperatively, and the extent of skin flap survival was compared between the experimental groups and control. Vitality of the flap and survival area was measured by infrared termography. Results: The topically applied methylprednisolon and pentadecapeptide BPC-157 resulted in statistically significant decrease in skin flap necrosis, compared with the control group (p< 0.05). The topically applied methylprednisolon and pentadecapeptide BPC-157 was effective in reducing ischemic necrosis in failing random pattern skin flaps in this rat model. Conclusion: The results of this study suggest that topical application of certain drugs might have applications as prophylactic therapy for risky skin flaps. Thermography of the skin is an easy method for estimating the vitality and survival area of the skin flaps.

flap survival; corticosteroids; pentadecapeptid BPC 157

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