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Pregled bibliografske jedinice broj: 227865

Regulatory T cells in children allergic to house dust mite undergoing specific immunotherapy


Ajduk, Jakov; Aberle, Neda; Rabatić, Sabina; Gagro, Alenka
Regulatory T cells in children allergic to house dust mite undergoing specific immunotherapy // Abstract book, OGAI (Austrian Society for Allergology and Immunology) Annual Meeting 2003
Salzburg, Austrija, 2003. (predavanje, međunarodna recenzija, sažetak, ostalo)


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Naslov
Regulatory T cells in children allergic to house dust mite undergoing specific immunotherapy

Autori
Ajduk, Jakov ; Aberle, Neda ; Rabatić, Sabina ; Gagro, Alenka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Abstract book, OGAI (Austrian Society for Allergology and Immunology) Annual Meeting 2003 / - Salzburg, Austrija, 2003

Skup
OGAI Annual Meeting 2003

Mjesto i datum
Salzburg, Austrija, 04-06.12.2003

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
regulatory T cells;
(regulatory T cells; immunotherapy; allergen)

Sažetak
Regulatory T cells (Treg) are defined by their surface phenotype (CD4+CD25+CD45RO+CD69-CTLA-4+) or by their ability to secrete immunoregulatory cytokines, such as interleukin (IL)-10 and transforming growth factor (TGF)- β . The aim of this study was to detect Treg in peripheral blood from children allergic to Dermatophagoides pteronyssinus undergoing specific immunotherapy (n=15). Treg were identified using four-color flow cytometry prior to, after three months, and after one year of immunotherapy. In addition, intracellular detection of IL-10 and TGF- β in T cells was performed. The level of CTLA-4 expressing Tregs increased transitory after 3 months of immunotherapy. While no changes in IL-10 secreting T-cells were found, specific immunotherapy increased percentage of TGF-β secreting T cells. These results indicate that analysis of CTLA-4 and TGF- β by flow cytometry could be useful markers to monitor the effect of specific immunotherapy in allergic individuals.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
0021004
0021001

Ustanove:
Imunološki zavod d.d.,
Opća bolnica "Dr. Josip Benčević"

Profili:

Avatar Url Jakov Ajduk (autor)

Avatar Url Neda Aberle (autor)

Avatar Url Alenka Gagro (autor)

Avatar Url Sabina Rabatić (autor)


Citiraj ovu publikaciju:

Ajduk, Jakov; Aberle, Neda; Rabatić, Sabina; Gagro, Alenka
Regulatory T cells in children allergic to house dust mite undergoing specific immunotherapy // Abstract book, OGAI (Austrian Society for Allergology and Immunology) Annual Meeting 2003
Salzburg, Austrija, 2003. (predavanje, međunarodna recenzija, sažetak, ostalo)
Ajduk, J., Aberle, N., Rabatić, S. & Gagro, A. (2003) Regulatory T cells in children allergic to house dust mite undergoing specific immunotherapy. U: Abstract book, OGAI (Austrian Society for Allergology and Immunology) Annual Meeting 2003.
@article{article, year = {2003}, pages = {40}, keywords = {regulatory T cells, }, title = {Regulatory T cells in children allergic to house dust mite undergoing specific immunotherapy}, keyword = {regulatory T cells, }, publisherplace = {Salzburg, Austrija} }
@article{article, year = {2003}, pages = {40}, keywords = {regulatory T cells, immunotherapy, allergen}, title = {Regulatory T cells in children allergic to house dust mite undergoing specific immunotherapy}, keyword = {regulatory T cells, immunotherapy, allergen}, publisherplace = {Salzburg, Austrija} }




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