Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 227503

Levosimendan as a New Strategy During Off-pump Coronary Artery Bypass Grafting: Double-blind Randomized Placebo-controlled Trial


Husedžinović, Ino; Barišin, Stjepan; Bradić, Nikola; Barišin, Ana; Sonički, Zdenko; Milanović, Rudolf
Levosimendan as a New Strategy During Off-pump Coronary Artery Bypass Grafting: Double-blind Randomized Placebo-controlled Trial // Croatian medical journal, 46 (2005), 6; 950-956 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 227503 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Levosimendan as a New Strategy During Off-pump Coronary Artery Bypass Grafting: Double-blind Randomized Placebo-controlled Trial

Autori
Husedžinović, Ino ; Barišin, Stjepan ; Bradić, Nikola ; Barišin, Ana ; Sonički, Zdenko ; Milanović, Rudolf

Izvornik
Croatian medical journal (0353-9504) 46 (2005), 6; 950-956

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Levosimendan; Off-pump cardiac surgery; hemodynamic

Sažetak
Aim was to determine if levosimendan could improve cardiac performance during off-pump coronary artery bypass grafting in patients with normal preoperative left ventricular function. Twenty-four patients included in this double-blind randomized controlled trial received either placebo (n=12) or 12  g/kg loading dose of levosimendan (n=12) during a period of 15 minutes before the surgery. The heart rate, cardiac index, stroke volume index, and left ventricular ejection fraction were measured before and 10 and 60 minutes after the drug administration. The baseline measurements of hemodynamic parameters did not differ between the groups. Heart rate was not significantly different between the placebo and levosimendan group. Compared with placebo group, cardiac index and left ventricular ejection fraction were significantly higher 10 and 60 minutes (p=0.018 for all) after administration of levosimendan. After 60 minutes, the cardiac index increased from the baseline value of 2.18 L/min/m2 to 2.84 L/min/m2. Left ventricular ejection fraction increased by 14% after 10 minutes, and by 10% after 60 minutes. Stroke volume index was significantly higher at 10 minutes (p=0.018), but not at 60 minutes (p=0.063) after the administration of levosimendan. Administration of 12  g/kg of levosimendan enhances the left ventricular performance and offers a promising therapeutic option during off-pump coronary artery bypass grafting in patients with good preoperative left ventricular function.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
0198019

Ustanove:
Klinička bolnica "Dubrava"

Citiraj ovu publikaciju

Husedžinović, Ino; Barišin, Stjepan; Bradić, Nikola; Barišin, Ana; Sonički, Zdenko; Milanović, Rudolf
Levosimendan as a New Strategy During Off-pump Coronary Artery Bypass Grafting: Double-blind Randomized Placebo-controlled Trial // Croatian medical journal, 46 (2005), 6; 950-956 (međunarodna recenzija, članak, znanstveni)
Husedžinović, I., Barišin, S., Bradić, N., Barišin, A., Sonički, Z. & Milanović, R. (2005) Levosimendan as a New Strategy During Off-pump Coronary Artery Bypass Grafting: Double-blind Randomized Placebo-controlled Trial. Croatian medical journal, 46 (6), 950-956.
@article{article, year = {2005}, pages = {950-956}, keywords = {Levosimendan, Off-pump cardiac surgery, hemodynamic}, journal = {Croatian medical journal}, volume = {46}, number = {6}, issn = {0353-9504}, title = {Levosimendan as a New Strategy During Off-pump Coronary Artery Bypass Grafting: Double-blind Randomized Placebo-controlled Trial}, keyword = {Levosimendan, Off-pump cardiac surgery, hemodynamic} }
@article{article, year = {2005}, pages = {950-956}, keywords = {Levosimendan, Off-pump cardiac surgery, hemodynamic}, journal = {Croatian medical journal}, volume = {46}, number = {6}, issn = {0353-9504}, title = {Levosimendan as a New Strategy During Off-pump Coronary Artery Bypass Grafting: Double-blind Randomized Placebo-controlled Trial}, keyword = {Levosimendan, Off-pump cardiac surgery, hemodynamic} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





Contrast
Increase Font
Decrease Font
Dyslexic Font