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Pregled bibliografske jedinice broj: 224438

The application of LC-NMR and LC-MS for the separation and rapid structure elucidation of an unknown in 5-aminosalicylic acid


Novak, Predrag; Tepeš, Predrag; Fistrić, Ines, Bratoš, Igor; Gabelica, Vesna
The application of LC-NMR and LC-MS for the separation and rapid structure elucidation of an unknown in 5-aminosalicylic acid // Journal of Pharamaceutical and Biomedical Analysis, 40 (2006), 5; 1268-1272 (međunarodna recenzija, članak, znanstveni)


Naslov
The application of LC-NMR and LC-MS for the separation and rapid structure elucidation of an unknown in 5-aminosalicylic acid

Autori
Novak, Predrag ; Tepeš, Predrag ; Fistrić, Ines, Bratoš, Igor ; Gabelica, Vesna

Izvornik
Journal of Pharamaceutical and Biomedical Analysis (0731-7085) 40 (2006), 5; 1268-1272

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
5-Aminosalicylic acid; Impurity; Liquid chromatography– nuclear magnetic resonance spectroscopy; Liquid chromatography– mass spectrometry

Sažetak
UNCORRECTED PROOF Thiswork has demonstrated the usefulness of combining liquid chromatography- nuclear magnetic resonance spectroscopy (LC- NMR) and liquid chromatography- mass spectrometry (LC- MS) methodologies for a rapid identification of an unknown impurity (N1) in the drug 5-aminosalycilic acid. Complementary information obtained from the two methods has revealed plenty of structural information and led to the fast on-line structure determination of N1 prior to its isolation and purification. The analysis of LC-NMR and LC- MS spectra revealed that N1 and 5-aminosalycilic acid are structurally closely related compounds. The structure of N1was later confirmed by high-resolutionNMRspectroscopy of the isolated compound and the atom assignment was made. The approach described here has potential for 5-aminosalycilic acid impurity profiling and monitoring the production process.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
0119641

Ustanove
Prirodoslovno-matematički fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Chemical Abstracts