Membranska metaloendopeptidaza (CD10/CALLA): rasprostranjenost, fizioloske i patofizioloske funkcije i inhibitori (CROSBI ID 82491)
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Podaci o odgovornosti
Stanović, Silvana ; Boranić, Milivoj
hrvatski
Membranska metaloendopeptidaza (CD10/CALLA): rasprostranjenost, fizioloske i patofizioloske funkcije i inhibitori
Membranska metaloendopeptidaza (EC 3.4.24.11, enkefalinaza, neutralna endopeptidaza, NEP) stanični je ektoenzim, a imunofenotipski se očituje kao leukocitni antigen CD10/CALLA. To je membransko obilježje identificirano imunološkim, biokemijskim i molekularno-biološkim tehnikama u različitim organima: mozgu, krvotvornom i kardiovaskularnom sustavu, plućima, placenti, bubregu i dr. Imunofenotip CD10/NEP svojstven je blastima limfoidne leukemije koji ne izražavaju obilježja T i B. Proteolitičkim cijepanjem hemoregulacijskih peptida CD10/NEP vjerojatno utječe na ontogenezu limfocita. Supstrati CD10/NEP u bubrezima su (v. popis skraćenica) ANP, adrenomedulin i PAMP; u mozgu enkefalini i oksitocin; u plućima bombezin i njemu slični peptid GRP te neuromedin C, supstancija P i neurokinin A; u kardiovaskularnom sustavu supstrati CD10/NEP su bradikinin, angiotenzin II i CGRP; u crijevu VIP; a na membrani neutrofilnih leukocita fMLP i drugi. Pojedini supstrati nisu strogo tkivnospecifični, primjerice supstancija P. U pretkliničkim se i kliničkim pokusima istražuju mogućnosti terapijske primjene inhibitora neutralne endopeptidaze, primjerice tiorfana, kao analgetika i antidepresiva te antidijaroika, antihipertenziva i antiastmatika. Potencijalne mogućnosti primjene su terapija hijalinomembranske bolesti prijevremeno rođene djece i sprečavanje neurotoksikoze kod tetanusa i botulinizma.
membranska metaloendopeptidaza (EC 3.4.24.11); neutralna endopeptidaza; enkefalinaza; CD10/CALLA
nije evidentirano
engleski
Membrane metalloendopeptidase (CD10/CALLA): distribution, physiological and pathophysiological functions, inhibitors
Membrane rnetalloendopeptidase EC 3.4.24.11 (Enkephalinase, neutral endopeptidase, NEP) is a cellular ectoenzyme, immunophenotypically identified as the leukocyte cluster of differentiation CDI0 or CALLA (common acute lymphoblastic leukemia antigen). Immunological, biochemical and molecular biology techniques have identified tis cell membrane feature in various organs: brain, cardiovascular system, lung, placenta, kidney etc. The CDIO irnmunophenotype is a common feature of lymphoblasts in acute lymphoid leukemia not expressing the T- or B-markers. The enzymatic activity of CD 10/NEP possibly influences nonnal lymphocyte ontogeny by proteolytic cleavage of the regulatory peptides. The substrates of CDl0/NEP in the kidneys are (see the list of abbreviations) ANP, adrenomedullin and PAMP; in the brain, the substrates are enkephalins and oxytocin; in the lung, bombesin, BLP, GRP, neuromedin C, substance P and neurokinin A; in the cardiovascular system, angiotenisin II, bradykinin and CGRP; in the gut, VIP; on the neutrophil membrane, fMLP etc. Some substrates are not strictly tissue-specific, e. g. substance P. Preclinical and clinical trials explore possibilities of therapeutic application of the inhibitors of neutral endopeptidase, such as thiorphan in the management of pain, diarrhoea, depression, arterial hypertension and asthma. Other possibilities of application include the treatment of hyalinomembranous disease and prevention of neurotoxicosis in tetanus and botulism.
membrane metalloendopeptidase (EC 3.4.24.11); neutral endopeptidase; enkephalinase; CD10/CALLA
nije evidentirano
Podaci o izdanju
120 (5)
1998.
131-137
objavljeno
0024-3477
1849-2177
