engleski

Controlled trial of the prophylactic administration of antibiotics in sclerotherapy of esophageal varices

The aim of this controlled trial was to determine the usefulness of chemoprophylaxis in sclerotherapy of ruptured esophageal varices. Sixty patients bleeding from esophageal varices, without signs of infection at admission, were included in a randomised open trial of one-year duration. Thirty patients received, along with the usual standard therapy (infusions, transfusions) 4x1g ampicillin intravenously over 3 days, and 30 patients received the standard therapy only. Bleeding varices of the esophagus were sclerosed transendoscopically intravenously using 1% polidocanol solution. Body temperature, general condition, white blood count, differential blood count and sedimentation rate were followed-up over three days. There were no statistically significant differences between tehe groups in the mean values of the mentioned parameters. There was no correlation betweent he dose of sclerosant used and body temperature or leukocyte count. Chemoprophylaxis proved to have no effect in this indication.

bleeding esophageal varices; varices sclerotherapy; chemoprophylaxis; ampicillin

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