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Derivati N-benzil-3-amidokinuklidina kao inhibitori butirilkolinesteraze (CROSBI ID 512522)

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Odžak, Renata ; Tomić, Srđanka Derivati N-benzil-3-amidokinuklidina kao inhibitori butirilkolinesteraze // XIX Hrvatski skup kemičara i kemijskih inženjera Opatija, Hrvatska, 24.04.2005-27.04.2005

Podaci o odgovornosti

Odžak, Renata ; Tomić, Srđanka

hrvatski

Derivati N-benzil-3-amidokinuklidina kao inhibitori butirilkolinesteraze

Racemates as well as enantiomers of 3-amidoquinuclidine derivatives of acetic, pivalic, butyric and benzoic acid were prepared. Racemates and enantiomers of quaternary N-benzyl derivatives were synthesized as well by quaternization with benzyl bromide. Structures of all synthesized amides were established by spectroscopy (IR, MS, 1D and 2D NMR) and optical rotations measurements. Butyrylcholinesterase (BChE) was tested with a series of other enzymes as a possible biocatalyst in the hydrolysis of prepared racemic amides, but it was shown that hydrolysis did not occur. Taking into account this result and previously reported results on inhibitions of BChE by N-quaternary esters of quinuclidin-3-ol, N-benzyl amides were tested as possible inhibitors of BChE, as well. In experiments in which benzoylcholine was used as a substrate, it was shown that tested amides were inhibitors of BChE, the strongest of which was (S)-N-benzyl-3-benzamidoquinuclidinium bromide, (Ki=3.7 mikroM).

butyrylcholinesterase; inhibition; 3-amidoquinuclidin; N-benzyl derivatives

nije evidentirano

engleski

N-BENZYL-3-AMIDOQUINUCLIDINE DERIVATIVES AS INHIBITORS OF BUTYRYLCHOLINESTERASE

nije evidentirano

butirilkolinesteraza; inhibicija; 3-amidokinuklidin; N-benzil derivati

nije evidentirano

Podaci o prilogu

nije evidentirano

nije evidentirano

Podaci o skupu

XIX Hrvatski skup kemičara i kemijskih inženjera

predavanje

24.04.2005-27.04.2005

Opatija, Hrvatska

Povezanost rada

Kemija