engleski

Gamma Knife Radiosrgery – Zagreb Experience

Gamma Knife radiosurgery (GKRS) is increasingly being used in neurosurgery as minimally invasive procedure over the last decade. This is a technique designed to deliver a high dose of focused radiation to a defined target volume to elicit a desired radiobiological response. This response depends on the radiation dose, the nature of the tissue, and the time elapsed after radiosurgery. The desired response for a vascular malformation is obliteration of the abnormal vessels, whereas for tumors, it is long term growth control.Radiosurgery is a radical departure from the general approach of clinical fractionated radiation therapy, which gradually evolved during the last century. Radiosurgery, in contrast to fractionated radiation therapy, entails the use of a high dose of precisely focused radiation delivered in a single session. Its effect on the surrounding normal tissue is limited by the highly focused nature of radiosurgical beams. Unlike conventional radiotherapy, radiosurgery is used to treat small volumes of tissue with much higher single-fraction doses. Whereas fractionated radiotherapy is generally most effective in killing rapidly dividing cells, radiosurgery is thought to arrest the cell division capability of target cells irrespective of their mitotic activity, oxygenation, and inherent radio sensitivity. The purpose of this paper is to present initial 14 months experience with Leksell Gamma Knife model C in Zagreb. During this period we have treated over 340 patients with different intracranial lesions. Although the follow up is short, we present initial results and discus indications for such treatment.

gamma knife; radiosurgery; focused radiation

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