engleski

Botulinum Toxin Type A Reduces Muscle Hyperalgesia in the Rat.

Muscle hyperalgesia in rats was induced with repeated intramuscular acidic saline injections (Sluka KA et al, Muscle Nerve 24:37, 2001). Right gastrocnemius muscle was injected twice with 100 microL l of pH 4 saline four days apart. Rats in one group received botulinum toxin type A (BTX-A ; 5 U/kg) into the plantar surface of the right hind-paws 5 days before the first acidic saline injection, while the second group received BTX-A on the contralateral side. Sensitivity to mechanical stimuli was measured outside the site of injection, on the hind-paws, using the paw-pressure test. Statistics: ANOVA, intergroup differences: Newman-Keuls post hoc test. After the second intramuscular acidic saline injection, significant bilateral hypersensitivity (p<0.01) to mechanical stimuli compared to the control group of rats was observed. Pre-treatment with BTX-A prevented the development of mechanical hyperalgesia on both sides (p<0.001) only when the toxin was injected into the ipsilateral hind-paws. However, when applied contralaterally, the toxin inhibited the development of hypersensitivity on contralateral side only. These results demonstrate the effectiveness of BTX-A in prevention of secondary mechanical hyperalgesia induced by muscle injury. Support: Croatian Ministry of Science, Education and Sport and Deutscher Akademischer Austausch Dienst.

Botulinum toxin; pain

nije evidentirano