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Pregled bibliografske jedinice broj: 219230

Antinociceptive effect of botulinum toxin type a in rat model of carrageenan and capsaicin induced pain.


Bach-Rojecky, Lidija; Lacković, Zdravko
Antinociceptive effect of botulinum toxin type a in rat model of carrageenan and capsaicin induced pain. // Croatian medical journal, 46 (2005), 2; 201-208 (međunarodna recenzija, članak, znanstveni)


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Naslov
Antinociceptive effect of botulinum toxin type a in rat model of carrageenan and capsaicin induced pain.

Autori
Bach-Rojecky, Lidija ; Lacković, Zdravko

Izvornik
Croatian medical journal (0353-9504) 46 (2005), 2; 201-208

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
botulinum toxin type A; pain; antinociception; capsaicin; carrageenan

Sažetak
AIM: To test antinociceptive properties of botulinum toxin type A (BTX-A) in rats with carrageenan- and capsaicin-induced pain and inflammation. METHODS: Pain was provoked with carrageenan (1%) or capsaicin (0.1%) injection into the plantar surface of the rat paw-pad. The effect of BTX-A 5 U/kg on carrageenan- and capsaicin-induced mechanical and thermal hypersensitivity, as well as the size of carrageenan-induced paw edema were tested 24 hours and 6 days following the toxin injection into the rat paw-pad. In the dose-response experiment, the effect of different doses of BTX-A (2, 3, 3.5, 5, and 7 U/kg) on carrageenan-induced mechanical hypersensitivity was investigated on day 5 after BTX-A application. RESULTS: Pretreatment with 5 U/kg BTX-A significantly reduced or completely abolished the enhanced sensitivity to mechanical and thermal stimuli provoked by peripheral carrageenan or capsaicin injections. This reduction was significant when BTX-A was applied 6 days before the induction of pain and inflammation, but the toxin was ineffective when applied 24 hours before the challenge. In the dose-response experiment, the lowest effective dose was 3.5 U/kg, but apparently the effect was not dose-dependent. In contrast to the antinociceptive effect, 5 U/kg BTX-A had no effect on the carrageenan-induced paw edema. CONCLUSION: The study demonstrated the efficacy of peripherally applied BTX-A pretreatment on the pain component of inflammatory process in experimental animals.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
0108163

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Zdravko Lacković (autor)

Avatar Url Lidija Bach-Rojecky (autor)


Citiraj ovu publikaciju

Bach-Rojecky, Lidija; Lacković, Zdravko
Antinociceptive effect of botulinum toxin type a in rat model of carrageenan and capsaicin induced pain. // Croatian medical journal, 46 (2005), 2; 201-208 (međunarodna recenzija, članak, znanstveni)
Bach-Rojecky, L. & Lacković, Z. (2005) Antinociceptive effect of botulinum toxin type a in rat model of carrageenan and capsaicin induced pain.. Croatian medical journal, 46 (2), 201-208.
@article{article, year = {2005}, pages = {201-208}, keywords = {botulinum toxin type A, pain, antinociception, capsaicin, carrageenan}, journal = {Croatian medical journal}, volume = {46}, number = {2}, issn = {0353-9504}, title = {Antinociceptive effect of botulinum toxin type a in rat model of carrageenan and capsaicin induced pain.}, keyword = {botulinum toxin type A, pain, antinociception, capsaicin, carrageenan} }
@article{article, year = {2005}, pages = {201-208}, keywords = {botulinum toxin type A, pain, antinociception, capsaicin, carrageenan}, journal = {Croatian medical journal}, volume = {46}, number = {2}, issn = {0353-9504}, title = {Antinociceptive effect of botulinum toxin type a in rat model of carrageenan and capsaicin induced pain.}, keyword = {botulinum toxin type A, pain, antinociception, capsaicin, carrageenan} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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