Botulinum toxin type A in rat model of muscle hyperalgesia (CROSBI ID 510904)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Bach-Rojecky, Lidija ; Lacković, Zdravko ; Relja, Maja
engleski
Botulinum toxin type A in rat model of muscle hyperalgesia
Objective was to investigate the influence of botulinum toxin type A (BTX-A) on muscle hyperalgesia in rats induced with repeated intramuscular acidic saline injections. Right gastrocnemius muscle was injected twice with 100 l of pH 4 saline four days apart. Rat in one group received BTX-A ( 5 U/kg) into the plantar surface of the right hind-paws 5 days before injection, while the second group underweant the same treatment on the other side. After the second saline injection bilateral hypersensitivity (p<0.01) was observed. Pre-treatment with BTX-A prevented the development of hyperalgesia on both sides (p<0.01) only when toxin was injected into the ipsilateral hind-paws. When applied contralateraly the toxin inhibited the development of hypersensitivity on contralateral side only. These results demonstrate the effectivness of BTX-A in prevention of hyperalgesia induced by muscle injury.
botulinum toxin A; pain
Peter Franz Riederer, Susanne W. Burns, Manfred Gerlach (ur.) ; DOI: 10.1016/S1353-8020(05)80088-4 ; Riječ je o poster konferenciji na poziv, tj. o posteru i predavanju uz PP prezentaciju, odnosno o pozvanom predavanju.
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Podaci o prilogu
106-106.
2005.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Parkinsonism & related disorders
1353-8020
Podaci o skupu
International Congress on Parkinson's Disease and Related Disorders (16 ; 2005)
poster
01.01.2005-01.01.2005
Povezanost rada
Temeljne medicinske znanosti