engleski

Experimental models of Alzheimer's disease

It seems very likely that streptozotocin-icv (STZ-icv) rat model represents the probable experimetal model of sporadic Alzheimer’ s disease, not only regarding the similarity of cognitive deficits and reduced glucose/energy metabolism, but also regarding the impaired insulin receptor signalling transduction. In line with that, glucose transporter inhibitor (GLUT I)-icv rat model could also be considered as a probable experimental sporadic Alzheimer's disease model.

streptozotocin; insulin; sporadic Alzheimer's disease

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