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Pregled bibliografske jedinice broj: 215228

Increased activity of Pgp multidrug transporter in patients with Helicobacter pylori infection


Babić, Žarko; Svoboda-Beusan, Ivna; Kučišec-Tepeš, Nastja; Dekaris, Dragan; Troskot, Rosana
Increased activity of Pgp multidrug transporter in patients with Helicobacter pylori infection // World journal of gastroenterology, 11 (2005), 18; 2720-2725 doi:10.3748/wjg.v11.i18.2720 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 215228 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Increased activity of Pgp multidrug transporter in patients with Helicobacter pylori infection

Autori
Babić, Žarko ; Svoboda-Beusan, Ivna ; Kučišec-Tepeš, Nastja ; Dekaris, Dragan ; Troskot, Rosana

Izvornik
World journal of gastroenterology (1007-9327) 11 (2005), 18; 2720-2725

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
H pylori ; RMF ; Pgp

Sažetak
To determine whether local antibiotic resistance involves P-glycoprotein (Pgp)-mediated active drug outpumping during Helicobacter pylori (H pylori) infection treatment with classic antibiotic therapy. Pgp activity was determined in gastric mucosa biopsy specimens obtained from 53 patients with pathohistologically verified gastritis and microbiologically confirmed H pylori infection, and compared with the Pgp activity in 12 control subjects with normal endoscopic findings. The H pylori positive patients were treated with short-term 7-d therapy consisting of two antibiotics (amoxicillin and azithromycin/metronidazole and clarithromycin) and a proton pump inhibitor. Pgp activity was determined by flow cytometry in the test of rhodamine dye efflux and quantified as mean fluorescence ratio (RMF). Upon the first cycle, H pylori was successfully eradicated in 20 patients, whereas therapy was continued in 33 patients. In the course of antibiotic therapy, RMF increased (P<0.05) and gastric cells showed higher rhodamine dye efflux. The mean pre-treatment RMF values were also higher (P<0.0001) in patients with multiple therapeutic failure than in those with successful H pylori eradication and control subjects. Pgp might be one of the causes of therapy failure in patients with H pylori and antibiotic therapy could be chosen and followed up on the basis of the Pgp transporter local activity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
0021001

Ustanove:
Imunološki zavod d.d.,
Klinička bolnica "Sveti Duh"

Citiraj ovu publikaciju

Babić, Žarko; Svoboda-Beusan, Ivna; Kučišec-Tepeš, Nastja; Dekaris, Dragan; Troskot, Rosana
Increased activity of Pgp multidrug transporter in patients with Helicobacter pylori infection // World journal of gastroenterology, 11 (2005), 18; 2720-2725 doi:10.3748/wjg.v11.i18.2720 (međunarodna recenzija, članak, znanstveni)
Babić, Ž., Svoboda-Beusan, I., Kučišec-Tepeš, N., Dekaris, D. & Troskot, R. (2005) Increased activity of Pgp multidrug transporter in patients with Helicobacter pylori infection. World journal of gastroenterology, 11 (18), 2720-2725 doi:10.3748/wjg.v11.i18.2720.
@article{article, year = {2005}, pages = {2720-2725}, DOI = {10.3748/wjg.v11.i18.2720}, keywords = {H pylori, RMF, Pgp}, journal = {World journal of gastroenterology}, doi = {10.3748/wjg.v11.i18.2720}, volume = {11}, number = {18}, issn = {1007-9327}, title = {Increased activity of Pgp multidrug transporter in patients with Helicobacter pylori infection}, keyword = {H pylori, RMF, Pgp} }
@article{article, year = {2005}, pages = {2720-2725}, DOI = {10.3748/wjg.v11.i18.2720}, keywords = {H pylori, RMF, Pgp}, journal = {World journal of gastroenterology}, doi = {10.3748/wjg.v11.i18.2720}, volume = {11}, number = {18}, issn = {1007-9327}, title = {Increased activity of Pgp multidrug transporter in patients with Helicobacter pylori infection}, keyword = {H pylori, RMF, Pgp} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Chemical Abstracts
  • Excerpta Medica
  • Index Medicus
  • PubMed
  • Abstracts Journals
  • Nature Clinical Practice Gastroenterology and Hepatology
  • CAB Abstracts and Global Health


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