Functional elements residing within satellite DNAs (CROSBI ID 117429)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Ugarković, Đurđica
engleski
Functional elements residing within satellite DNAs
Satellite DNAs represent a fast-evolving portion of the eukaryotic genome whose evolution is proposed to be driven by the stochastic process of molecular drive. Recent results indicate that satellite DNAs are subject to certain structural constraints, which are probably related to their interaction with proteins involved in the establishment of specific chromatin structures. The evolutionary persistence and high sequence conservation of some satellites as well as the presence of stage- or tissue-specific, differentially expressed transcripts in several species are consistent with the hypothesis that satellite DNA could have a regulatory role in eukaryotic organisms. Although the role of most transcripts is not known, some act as precursors of siRNAs, which are now recognized as having an important role in chromatin modulation and the control of gene expression. Furthermore, some transcripts are involved in the cellular response to stress.
repetitive DNA; heterochromatin; CENP-B box; noncoding RNA; gene regulation
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